5 Best berberine supplements for blood sugar control

Managing blood sugar levels is a crucial aspect of maintaining overall health, especially for those with diabetes or pre-diabetes. 

Among the various natural supplements gaining popularity for this purpose is berberine, known for its potential benefits in regulating glucose levels. 

This blog aims to introduce readers to five top berberine supplements that can be incorporated into their health regimen for better blood sugar control. 

Each product will be evaluated based on its features, benefits, user reviews, pricing, and availability, providing a comprehensive guide to help you make an informed choice. Let’s explore these options together.

ProHealth Longevity Berberine Pro 600 mg

Product overview

ProHealth Longevity’s Berberine Pro 600 Mg is a premium supplement designed to support various aspects of health. 

It aids in healthy aging by activating AMPK, a critical enzyme in metabolic regulation, and improves body composition. 

This supplement not only enhances heart health but also plays a vital role in managing blood sugar levels​​.

Key features

Each capsule of Berberine Pro contains 600 mg of Berberine HCL, along with 50 mg of Alpha Lipoic Acid and 10 mg of Bioperine Black Pepper Fruit Extract. 

The inclusion of these additional ingredients boosts the overall efficacy of the supplement, particularly in terms of absorption and metabolic support​​.

Benefits for blood sugar control

Berberine has been recognized for its ability to support healthy fasting blood sugar and insulin levels. 

This control over blood sugar regulation can lead to weight management benefits, including curbing excessive cravings. 

The activation of berberine-triggered AMPK leads to promising health benefits, making it an effective tool to regulate blood sugar levels.

Suggested daily use

The recommended dosage is one capsule taken twice daily with food high in fat, following a cycle of five days on and two days off. 

This regimen is suggested for optimal absorption and effectiveness. Users should consult with healthcare professionals, especially if they have existing medical conditions or are on medication, due to potential interactions and effects on blood sugar levels​​.

Pricing and manufacturing quality

Priced at $29.95 for a bottle of 60 capsules, ProHealth Longevity Berberine Pro offers quality at a reasonable cost. 

The product is manufactured in an FDA-registered, GMP-certified facility, ensuring high standards of quality and purity. 

Each batch undergoes third-party testing in the USA, with Certificates of Analysis available for transparency and assurance​​​​.

For more information and to purchase ProHealth Longevity Berberine Pro 600 Mg, visit their product page.

prohealth longevity berberine pro

Botanic Choice Berberine 500

Product overview

Botanic Choice offers Berberine 500 Mg Vegetarian Capsules, a supplement derived from a class of alkaloids found in several plants like goldenseal and European barberry. 

With a rich history in traditional Chinese and Ayurvedic medicine, this yellow-colored compound has been used for various health concerns over the centuries. Its recent popularity is due to its ability to regulate blood sugar and cholesterol levels.

Key features

Each vegetarian capsule contains 500 mg of berberine, and dosage research suggests it is effective for supporting blood sugar and cholesterol health. This product is presented in vegetable capsules, making it suitable for vegetarians​​.

Benefits for blood sugar control

Botanic Choice’s berberine is known to support blood sugar and cholesterol levels already within the normal range. 

It works through its involvement with the AMPK enzyme, which plays a critical role in metabolic function, insulin function, cardiovascular health, and even weight management. 

This makes it an integral supplement for those looking to maintain these aspects of their health​​​​.

Suggested use

The recommended usage is one capsule taken twice daily after a meal. This regimen should be followed as directed by a healthcare professional to ensure optimal results and safety​​.

Pricing and availability

Priced at $24.99 for a bottle containing 60 vegetarian capsules, Botanic Choice Berberine offers a valuable option for those seeking a high-quality, vegetarian-friendly berberine supplement.  It balances affordability and quality, making it accessible to a broad audience​​.

To learn more and purchase Botanic Choice Berberine 500 Mg Vegetarian Capsules, visit the product page.

botanic choice berberine

Double Wood Supplements

Product overview

Double Wood Supplements offers a berberine supplement that has garnered attention for its multiple health benefits. 

Extracted from plants with a strong background in traditional Chinese medicine, this supplement primarily promotes healthy cholesterol levels. 

Additionally, it supports cardiovascular and cognitive functions, making it a multifaceted choice for health-conscious individuals​​.

Key features

Each capsule contains 500 mg of berberine, with the recommended dosage being one to four capsules daily. 

It’s advised to space out the intake by at least three hours to avoid gastrointestinal side effects. 

This supplement is best taken with or directly after meals for maximum effect on cholesterol​​.

Benefits for blood sugar control

While berberine’s primary use is for cholesterol management, its impact on blood sugar control is significant. Its properties as a powerful antioxidant contribute to its ability to support healthy cognitive functions, an added advantage for users​​​​.

User reviews and safety

Most users tolerate Double Wood’s berberine well, with reports of improved health markers. 

Common side effects include stomach upset, cramping, and diarrhea, particularly if more than one capsule is consumed at a time. 

It’s essential to consult a physician before combining it with prescription medications to avoid adverse reactions​​.

Pricing, availability, and allergen information

The Double Wood Supplements Berberine is priced at $19.95 for a bottle containing 60 capsules, each with 500 mg of berberine. 

This competitive pricing makes it an affordable option for those seeking to incorporate this supplement into their health routine. It is readily available for purchase online, ensuring easy accessibility. 

Additionally, this supplement caters to various dietary needs and preferences as it is soy-free, gluten-free, non-GMO, and vegan. Manufactured in the USA, it meets high-quality production standards, making it a reliable choice for consumers.

For further details and to buy the product, visit the Double Wood Supplements Berberine product page.

double wood berberine

RENUE BY SCIENCE Liposomal Berberine

Product overview

RENUE BY SCIENCE introduces its Liposomal Berberine supplement, distinctively formulated for optimal efficacy. This supplement utilizes advanced liposomal technology to enhance the absorption and systemic delivery of berberine.

Key features

The supplement employs liposomal encapsulation to overcome the low oral bioavailability of standard berberine. This innovative approach significantly improves the passage of berberine through the gastrointestinal tract, ensuring a higher percentage reaches the bloodstream.

Benefits for blood sugar control

Berberine, known for activating the AMPK enzyme, plays a pivotal role in regulating metabolism and maintaining healthy blood sugar levels. The enhanced absorption of this liposomal formula supports efficient glucose management and metabolic optimization.

For best results, the recommended usage of this liposomal berberine supplement is once daily, with or without food. The liposomal delivery method ensures comprehensive absorption and a sustained release, maximizing the bioavailability and effectiveness of berberine.


Priced at $49.95 for a bottle of 90 capsules, RENUE BY SCIENCE Liposomal Berberine offers an effective solution for those seeking a potent and well-absorbed berberine supplement.

To learn more and purchase, visit the RENUE BY SCIENCE Liposomal Berberine product page.

renue by science lipo berberine

Solaray Berberine 500mg

Product overview

Solaray’s Berberine 500mg supplement is recognized as a potent health support, with a history spanning over three thousand years. 

This particular formula guarantees to deliver 500 mg of berberine root extract from Indian barberry, highlighting its commitment to traditional wellness practices.

Key features

The key ingredients in this supplement include Berberine HCl sourced from Indian Barberry, Whole Rice Concentrate, and Vegetable Cellulose for the capsule. 

This combination ensures a natural and effective formulation suitable for various dietary preferences and needs​​.

Benefits for blood sugar control

Berberine is well-known for its benefits in supporting overall health, including the management of blood sugar levels. 

By delivering a substantial 500mg dose per capsule, Solaray’s Berberine 500mg provides an effective means to incorporate this traditional herb into a modern health regimen for those focusing on blood glucose management.


The recommended direction for use is to take one VegCap daily with a meal or glass of water. This simple and straightforward dosage is designed for ease of incorporation into daily health routines, making it accessible for consistent use​​.

Pricing and environmental commitment

Priced at $28.69 for a bottle containing 60 vegetarian capsules, Solaray Berberine 500mg offers an affordable option for quality health supplementation. 

Solaray is also committed to environmental sustainability, using recycled packaging, responsibly sourcing high-quality ingredients, and engaging in eco-friendly initiatives such as planting trees and using solar energy at their facilities​​​​.

For further information and to purchase Solaray Berberine 500mg, you can visit the product page.

solaray berberine

Closing thoughts

These five berberine supplements offer unique benefits and features tailored to support blood sugar and overall metabolic health. 

ProHealth Longevity and Botanic Choice provide specialized formulations for enhanced efficacy. Double Wood stands out for its purity and high-quality standards, RENUE BY SCIENCE offers advanced liposomal technology for superior absorption, and Solaray combines traditional wisdom with modern sustainability practices.

Choosing the right supplement depends on individual health needs and preferences, and it’s always advisable to consult with a healthcare professional for personalized guidance.

Explore the provided links for more details on each product and to find the best fit for your health journey.


Does berberine really help with blood sugar?

Berberine is known for its potential to help regulate blood sugar levels, making it a popular supplement for those managing glucose levels. Clinical studies have shown that it can positively impact blood sugar control, especially in conjunction with a healthy diet and lifestyle.

Does berberine really work like metformin?

Berberine has shown potential in studies to lower blood sugar levels similarly to metformin, a common diabetes medication. However, it is not a direct substitute and should be used under medical guidance, especially for those with diabetes.

How long does berberine take to lower blood sugar?

The effects of berberine on blood sugar levels can vary, but some studies suggest improvements can be observed within a few weeks to a few months of consistent use. However, individual responses may vary based on dosage and personal health factors.

Who should not take berberine?

Berberine should be avoided by pregnant or breastfeeding women, children, and those with certain medical conditions, particularly liver disease or low blood pressure. Individuals on medication, especially for diabetes or heart conditions, should consult a doctor before taking berberine.

Photograph: seventyfourimages/Envato
The information included in this article is for informational purposes only. The purpose of this webpage is to promote broad consumer understanding and knowledge of various health topics. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.