5 Foods rich in antinutrients and how to minimize their effects

In our quest for a balanced and nutritious diet, we often encounter conflicting information about the food we eat. One such intriguing group of compounds is antinutrients, which have gained attention for their potential adverse effects on health. 

Antinutrients are natural substances found in certain foods that can interfere with nutrient absorption and digestion, impacting the overall nutritional value of our diet.

While antinutrients are present in many foods, they also coexist with essential nutrients, making it vital to understand their role and potential impact on our well-being.

What is the importance of anti-nutrient?

Antinutrients are naturally occurring compounds found in many plant-based foods that act as a defense mechanism for plants.

These compounds serve to protect the plants from predators, pests, and environmental stressors, contributing to their survival in nature. 

While these defense mechanisms are essential for the plants’ survival, they can pose challenges for human nutrition when consumed in large quantities.

What are antinutrients and how do they work?

Antinutrients are a diverse group of compounds that interfere with the absorption and utilization of essential nutrients in the human body [1]. 

Although they vary in structure and mechanism, their common goal is to limit the availability of nutrients, particularly minerals and vitamins, making them less bioavailable to us.

  • Phytic acid: Found in seeds, nuts, grains, and legumes, phytic acid binds to minerals like iron, zinc, calcium, and magnesium, forming insoluble complexes that hinder their absorption.
  • Lectins: Lectins are proteins found in legumes, grains, and certain vegetables. They can resist digestion and bind to the lining of the intestines, potentially leading to digestive issues and inflammation.
  • Oxalates: Oxalates are naturally occurring compounds found in leafy greens, nuts, seeds, and certain fruits. When consumed in large amounts, oxalates can form crystals and contribute to the development of kidney stones.
  • Tannins: Tannins are polyphenolic compounds present in tea, coffee, wine, and certain fruits. While they possess antioxidant properties, excessive tannin consumption can hinder the absorption of iron and other minerals, leading to potential nutrient deficiencies.
  • Protease inhibitors: Mainly found in legumes, protease inhibitors interfere with the digestion of proteins by blocking specific enzymes that break down proteins. This may lead to digestive discomfort and potentially reduce protein utilization.
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Different types of antinutrients and their sources

Antinutrients are not inherently harmful, and in some cases, they may even confer health benefits when consumed in moderation. 

However, individuals with specific health conditions or diets that predominantly rely on antinutrient-rich foods should be cautious.

  • Legumes: Beans, lentils, and peas are common sources of both lectins and protease inhibitors. While legumes offer essential nutrients and fiber, proper preparation methods can reduce the levels of antinutrients and make them safer for consumption.
  • Whole grains: Cereal grains, such as wheat, rice, and oats, contain substantial amounts of phytic acid. The outer bran layer of grains is particularly rich in this antinutrient, making refined grains lower in phytic acid but also lower in essential nutrients.
  • Leafy greens: Spinach, Swiss chard, and beet greens are examples of leafy greens with high oxalate content. These vegetables are nutritious when consumed in moderation, but individuals with kidney stones or calcium-related health issues should be mindful of their oxalate intake.
  • Tea and coffee: While tea and coffee provide valuable antioxidants, their tannin content can interfere with the absorption of non-heme iron (plant-based iron). However, consuming these beverages between meals or with foods rich in vitamin C can enhance iron absorption.
  • Nightshades: Tomatoes, peppers, and eggplants belong to the nightshade family, containing lectins and other potentially irritating compounds. Cooking and processing can reduce lectin levels and make nightshades safer for consumption.

Why are antinutrients bad for you?

While antinutrients can play a protective role for plants, their presence in our diets can have significant implications for our health. 

These compounds can interfere with nutrient absorption, contribute to mineral deficiencies, and potentially affect our gut health and overall well-being.

Nutrient absorption and digestive issues

  • Impaired nutrient absorption

Antinutrients, such as phytic acid and tannins, can form complexes with essential minerals like iron, zinc, and calcium, preventing their efficient absorption in the gut.

This can lead to mineral deficiencies, weakening bones, impaired immune function, and overall compromised nutrient status.

  • Digestive disorders

Lectins and protease inhibitors found in legumes and other plant-based foods can resist digestion and bind to the lining of the intestines.

In some individuals, this can lead to digestive discomfort, bloating, gas, and even intestinal inflammation, causing conditions like irritable bowel syndrome (IBS).

digestive disorders

Mineral Deficiencies

  • Iron deficiency

The interference of antinutrients with iron absorption can be a significant concern, especially for individuals following plant-based diets. Iron deficiency anemia can result in fatigue, weakness, and decreased cognitive function [2].

  • Zinc deficiency

Zinc is essential for immune function, wound healing, and numerous enzymatic processes in the body.

Antinutrients, particularly phytic acid, can bind to zinc and reduce its bioavailability, leading to potential zinc deficiencies.

  • Calcium deficiency

Calcium is crucial for bone health and muscle function. High oxalate content in certain foods can hinder calcium absorption, potentially contributing to bone-related issues like osteoporosis.

Gut health and inflammation

  • Gut microbiome imbalance

Antinutrients, especially lectins, can impact the composition of the gut microbiome, potentially altering the balance of beneficial and harmful bacteria.

This imbalance may affect overall gut health and immune function.

  • Inflammation

Excessive consumption of antinutrient-rich foods may trigger inflammation in susceptible individuals, leading to chronic health issues and exacerbating conditions like arthritis or autoimmune diseases.

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How do you reduce antinutrients?

While some antinutrients can pose challenges to nutrient absorption and overall health, there are practical and effective methods to reduce their impact.

Employing specific food preparation techniques and making thoughtful food combinations can significantly decrease antinutrient levels, ensuring that we derive maximum nutrition from our diets.

Soaking and sprouting

  • Soaking grains and legumes: Soaking grains and legumes in water for a specified period before cooking can help reduce the levels of antinutrients like phytic acid. This process activates enzymes that break down these compounds, enhancing nutrient availability.
  • The magic of sprouting: Sprouting is a natural process that involves germinating seeds, grains, or legumes until they develop tiny shoots. Sprouting reduces antinutrients while increasing nutrient content, making the food more digestible and nutritious.


  • Transforming antinutrients: Fermentation is a traditional preservation method that involves the breakdown of antinutrients by beneficial microorganisms. This process reduces phytic acid, lectins, and tannins, making fermented foods easier on the digestive system.
  • Fermented foods: Incorporating fermented foods like yogurt, kefir, kimchi, sauerkraut, and miso into the diet can provide a wealth of probiotics and boost nutrient absorption while mitigating antinutrient effects.

Cooking techniques

  • Cooking to the rescue: Cooking grains, legumes, and vegetables can significantly reduce antinutrient levels. Boiling, steaming, and roasting are effective methods to make foods safer and enhance nutrient availability.
  • The art of blanching: Blanching vegetables involves briefly immersing them in boiling water and then rapidly cooling them. This process can reduce oxalate content and preserve nutrients.

Pairing and combining foods

  • The synergy effect: Combining certain foods can enhance nutrient absorption. For instance, pairing vitamin C-rich foods with iron-containing foods can improve iron absorption, counteracting the inhibitory effects of antinutrients.
  • Smart food pairings: Including diverse and balanced meals with a variety of nutrient sources can ensure that antinutrients’ negative impact is minimized while reaping the benefits of different foods.
pairing and combining foods

What is the truth about anti-nutrients?

Antinutrients have sparked numerous debates and misconceptions regarding their role in our diets [3]. 

It is essential to separate fact from fiction to make informed decisions about their consumption and overall impact on health.

Are antinutrients always harmful?

  • Unraveling the good side of antinutrients: While antinutrients can interfere with nutrient absorption, they also possess certain health benefits. For instance, some studies suggest that phytic acid may have antioxidant properties and could play a role in cancer prevention.
  • The dose makes the poison: Antinutrients’ harmful effects are often dose-dependent. Consuming small amounts of these compounds, especially when paired with a diverse diet, may not pose significant risks.

Raw vs. cooked foods: which is better?

  • The raw food trend: Raw food enthusiasts advocate for consuming foods in their uncooked state to preserve their nutrients. While this can be true for some nutrients, it is essential to recognize that cooking can neutralize antinutrients and enhance nutrient bioavailability [4]. 
  • Cooking and antinutrients: Cooking can reduce antinutrient levels and improve food digestibility. It also aids in breaking down complex compounds, making essential nutrients more accessible to our bodies.

Final thoughts

In pursuing a balanced and nutritious diet, understanding the role of antinutrients is crucial. 

These natural compounds in certain plant-based foods can impact nutrient absorption, potentially leading to mineral deficiencies and digestive issues. 

However, it is essential to approach antinutrients with a well-informed perspective, recognizing that they may offer certain health benefits in moderation.


Which foods contain high levels of phytic acid?

Foods like seeds, nuts, grains (especially bran), and legumes (beans, lentils, chickpeas) are known for their high phytic acid content.

How do antinutrients affect nutrient absorption?

Antinutrients, such as phytic acid and tannins, can bind to essential minerals like iron, zinc, calcium, and magnesium, forming complexes that hinder their absorption in the gut, potentially leading to mineral deficiencies.

Should I avoid all high-antinutrient foods?

It is not necessary to avoid all high-antinutrient foods. Instead, focus on moderation and proper preparation methods to minimize their impact while still enjoying their nutritional benefits.

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[1] https://www.sciencedirect.com/topics/food-science/antinutrients
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600777/
[3] https://www.futurelearn.com/info/courses/superfoods-myths-and-truths/0/steps/55710
[4] https://www.sciencedirect.com/science/article/pii/S1756464622000081

The information included in this article is for informational purposes only. The purpose of this webpage is to promote broad consumer understanding and knowledge of various health topics. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.