6 Common myths about fisetin, debunked

Fisetin, a naturally occurring plant polyphenol found in fruits like strawberries and apples [1], is steadily gaining attention in health and wellness.

Lauded for its potential anti-inflammatory, antioxidant, and neuroprotective properties, it’s no surprise that fisetin supplements are rising. 

However, with increasing popularity comes misinformation. As consumers, it’s crucial to discern fact from fiction to make informed choices.

This article debunks six common myths surrounding fisetin, clarifying what this fascinating compound truly offers.

What is fisetin?

Fisetin, scientifically classified as a flavonoid, is a vibrant yellow compound that occurs naturally in various fruits and vegetables

Most notably, strawberries are hailed for their rich fisetin content, but the compound can also be found in apples, grapes, onions, and cucumbers. Over the years, research has highlighted several potential health benefits of fisetin:

  • Antioxidant properties: Fisetin combats oxidative stress, pivotal in cellular aging and damage.
  • Anti-inflammatory capabilities: Fisetin has been of interest in studying chronic diseases, as inflammation is often at the heart of conditions like heart disease, diabetes and obesity [2].
  • Neuroprotection: Preliminary findings suggest fisetin may support brain health and offer a degree of protection against degenerative diseases such as Alzheimer’s.
what is fisetin
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How does fisetin work? 

Fisetin’s varied health benefits stem from its intricate mechanisms of action at the cellular and molecular levels. As a flavonoid, it plays a multifaceted role in modulating biological pathways, which are pivotal for maintaining human health.

Antioxidant pathways

Fisetin neutralizes free radicals by donating an electron, preventing cellular damage. Its antioxidant activity is also linked to the upregulation of antioxidant enzymes, amplifying the body’s defenses against oxidative stress.

Anti-inflammatory response

Fisetin inhibits key inflammatory pathways by suppressing the activation of NF-κB, a protein complex that plays a central role in inflammatory responses [3]. This action results in the decreased production of pro-inflammatory cytokines, reducing systemic inflammation.


The compound is believed to activate autophagy, a cellular “clean up” mechanism that removes damaged cells and proteins [4].

This process is crucial for neuronal health, potentially protecting against neurodegenerative diseases.

Fisetin also can inhibit pathways responsible for forming amyloid plaques associated with Alzheimer’s disease.

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Debunking 6 most common fisetin myths

1. Fisetin is an artificial supplement

Truth: Fisetin is inherently a natural compound, generously found in various fruits and vegetables, notably strawberries, apples, and onions.

Discussion: There is a misconception when it comes to the use of supplements. Yes, there are synthesized versions available that aim for purity and concentration. But these synthetic versions are often based on the natural structure of fisetin. 

Ideally, you should understand the source of your supplements. While natural fisetin derives directly from plant sources, synthetic versions are manufactured in labs.

Both can offer health benefits, but knowing the origin and choosing according to personal preferences and health recommendations is essential.

2. All fisetin supplements are the same

Truth: Not all fisetin supplements share the same quality or effectiveness. Significant variances exist due to differences in their source, extraction processes, and purity levels.

Discussion: Just as with any supplement or health product, the market contains a spectrum ranging from high-quality fisetin supplements to those of questionable standards. 

The extraction method, the purity of the end product, and even the location where the raw materials are sourced can influence the supplement’s overall effectiveness. 

Therefore, conducting thorough research, reading reviews, and possibly consulting health professionals is paramount to ensure you choose a quality brand that aligns with your health goals.

3. Fisetin is a miracle anti-aging solution

Truth: Fisetin, though recognized for its anti-aging properties, is not a panacea for all age-related concerns.

Discussion: Scientific research has showcased fisetin’s potential in combating oxidative stress, a significant contributor to cellular aging. However, it’s crucial to understand the broader context. 

While fisetin might help delay some aging processes, it’s not an elixir for eternal youth. Some studies underline its benefits but underscore its limitations, primarily when used in isolation.

A holistic approach to anti-aging, incorporating a balanced diet, exercise, and overall well-being, is far more effective than relying solely on one supplement.

4. Fisetin has no side effects

Truth: Contrary to popular belief, fisetin, like all supplements, isn’t devoid of side effects.

Discussion: While many individuals tolerate fisetin well, some might experience adverse reactions, ranging from gastrointestinal discomfort to allergic responses

Additionally, potential drug interactions could alter the efficacy of medications or exacerbate side effects. The variance in reactions highlights the importance of a personalized approach. 

It is crucial to consult a physician before incorporating fisetin or any supplement into your daily routine. This ensures safe consumption tailored to individual health profiles and minimizes potential risks.

5. More fisetin means better health outcomes

Truth: The assumption that consuming more fisetin leads to enhanced health benefits is a misstep. Optimal dosage is vital.

Discussion: Just as with any supplement or medication, there’s a balance to strike. Research indicates a recommended dosage range for fisetin to harness its potential benefits without venturing into side effects or diminishing returns. 

Excessive consumption can lead to unwanted reactions or even counteract the intended benefits.

It’s crucial to adhere to suggested dosages, often provided on supplement labels, or better yet, based on a healthcare professional’s advice, to ensure safe and effective use.

6. Fisetin is only helpful for the elderly

Truth: Fisetin’s benefits aren’t exclusive to older populations; all age groups can potentially benefit from its properties.

Discussion: While many tout fisetin’s neuroprotective effects as advantageous for the elderly, its antioxidant and anti-inflammatory attributes have widespread applications across various life stages. 

For younger individuals, fisetin can aid in combating oxidative stress from environmental factors, support immune function, and even aid in muscle recovery post-exercise. 

Recognizing fisetin as a holistic health enhancer rather than an age-specific supplement broadens its appeal and underscores its versatility in promoting wellness throughout one’s life.

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Is it safe to take fisetin? 

Fisetin’s popularity in the health community is backed by numerous studies highlighting its benefits. However, as with any supplement, it’s essential to approach its consumption with a discerning eye. Here are some factors to consider:

Dosage awareness

While many adults find the range of 100-500 mg daily suitable, it’s always wise to start on the lower end and adjust based on individual responses and needs.

dosage awareness
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Interactions with medications

Those on medications or with specific health conditions should be wary. A conversation with a healthcare professional can elucidate any potential interactions or contraindications.

Potential allergies

A minority might experience allergic reactions to fisetin. Initial small doses can help gauge individual tolerance, and any signs of allergies should prompt discontinuation.

Pregnancy considerations

The effects of fisetin during pregnancy or lactation aren’t extensively studied. It is advisable for pregnant or nursing mothers to be cautious and seek advice from a physician [5].

Quality matters

The market’s range in fisetin quality is vast. Opting for reputable, high-purity brands reduces risks associated with contaminants or subpar formulations.

Closing thoughts

Fisetin is becoming increasingly popular due to its potential health benefits. However, with this rise in popularity comes a risk of misunderstandings.

It’s important to understand the truth behind the myths, such as their natural origins and anti-aging promises, to make informed decisions about consumption. 

While fisetin holds promise in several health domains, it’s always essential to approach supplements holistically, recognizing them as part of a broader health strategy. 

By debunking these myths, we hope to clarify Fisetin’s genuine potential and guide individuals in making decisions that best align with their health goals and overall well-being.


Who should not take fisetin?

Individuals with known allergies to fisetin or its sources should avoid it. Additionally, those on medications or with underlying health conditions should consult a healthcare professional before taking fisetin to prevent potential adverse interactions or reactions.

Does fisetin harm kidneys?

Fisetin may benefit kidney function and reduce inflammation and apoptosis in mice with septic AKI. No evidence suggests it has any negative impact on the kidneys.

Which is better, quercetin or fisetin?

Quercetin and fisetin are flavonoids with antioxidant properties. The choice between them depends on personal health goals. Consult a healthcare professional for the best supplement for you.

How much fisetin is safe?

The optimal dosage of fisetin can vary based on individual factors and intended use, but general recommendations often fall within the range of 100-500 mg daily for adults. For personalized advice on safe and effective fisetin intake, it is recommended to consult with a healthcare professional.

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[1] https://en.wikipedia.org/wiki/Fisetin 
[2] https://dergipark.org.tr/en/download/article-file/1649692 
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009086/ 
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844953/ 
[5] https://supplements.selfdecode.com/blog/15-science-based-health-benefits-fisetin-1-favorite/

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The information included in this article is for informational purposes only. The purpose of this webpage is to promote broad consumer understanding and knowledge of various health topics. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.