7 Best topical peptides for skin you need to buy in 2024

Are you puzzled by the array of skincare ingredients claiming to turn back the clock on your complexion? Peptides might be the answer you’re searching for. 

Recent studies reveal that these tiny proteins play a pivotal role in skin health, signaling your cells to boost collagen and elastin production—key components for a firmer, smoother skin surface.

Choosing the right peptide-infused product, however, can be daunting. Your skin type, concerns, and desired outcomes should guide your selection. 

For oily skin, lightweight serums that don’t clog pores are ideal. These contain niacinamide, hyaluronic acid and salicylic acid [1]. Dry or mature skin types might benefit more from richer formulations offering hydration and peptide benefits [2]. 

And for those with sensitive skin, the focus should be on products with soothing peptides that reduce inflammation and repair the skin barrier [3].

This guide is designed to help you navigate through the top peptide formulations of 2024, highlighting which products suit your skin’s unique needs and why they deserve a spot in your skincare routine. 

We aim to provide you with the knowledge to make informed choices about peptides, ensuring you invest in products that align with your skincare goals. 

Let’s explore how these powerful ingredients can transform your skincare approach and lead to visibly healthier, more resilient skin.

What are the best peptides for the skin?

1. The Ordinary Multi-Peptide + HA Serum 

The Ordinary Multi-Peptide + HA Serum is a powerhouse of anti-aging innovation, cleverly combining a mix of peptides with hyaluronic acid to target multiple signs of aging simultaneously. 

This serum promises to hydrate deeply and smooth out fine lines and wrinkles, making it a versatile addition to any skincare routine. 

Its formulation improves skin texture and elasticity, providing a youthful, radiant complexion without harsh chemicals.

Good forNot for
• Anyone looking to fight the signs of aging without introducing harsh or irritating ingredients into their skincare regimen. 

• Its balanced formula supports skin health, making it suitable for a broad range of users, from those just starting to notice the first signs of aging to those with more mature skin seeking to maintain their complexion’s vitality.
• Those with extremely sensitive skin. 

• Although the complex blend of peptides is beneficial, it might cause reactions in the most delicate skin types. A patch test is recommended before fully integrating it into your routine.

Why should you buy it?

This serum is a must-have because of its affordability and potent blend of ingredients. It addresses hydration, aging, and skin texture concerns in one fell swoop, making it invaluable in your anti-aging arsenal.

Key ingredients

  • Matrixyl 3000 (combination of Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7) – This trademarked blend stimulates collagen production, potentially leading to firmer and smoother skin.
  • Dipeptide Diaminobutyroyl Benzylamide Diacetate – These additional peptides may target different aspects of aging, such as relaxing facial muscles to minimize wrinkles or supporting skin cell communication.
  • Hyaluronic acid – This humectant ingredient attracts and retains skin moisture, keeping it plump and hydrated [4].
  • Sodium hyaluronate – A smaller form of hyaluronic acid, it penetrates deeper into the skin to provide additional hydration [5].
  • Hydrolyzed hyaluronic acid – Even smaller than sodium hyaluronate, it can further enhance hydration and potentially improve product absorption [6].

2. Revision Skincare Revox 7

Revision Skincare Revox 7 stands out as a targeted solution for those battling expression lines and wrinkles. This innovative serum leverages a blend of seven distinct peptides, each chosen for its unique ability to combat the signs of aging

It’s a sophisticated formula designed to soften the appearance of expression lines without the need for invasive procedures, making it a staple in the regimen of anyone seeking to maintain a youthful visage through non-invasive means.

Good forNot for
• Individuals keen on addressing specific concerns like crow’s feet, forehead lines, and smile lines. 

• Its precise formulation offers visible results, catering to those who want to focus on reducing the appearance of expression lines that come with age or repeated facial movements.
• Those with very oily skin might find this serum less suitable, as its rich peptide formula could exacerbate oiliness. 

• Individuals with this skin type should consider lighter alternatives or patch test before committing to regular use.

Why should you buy it?

This serum is a targeted approach to aging, specifically formulated to address and reduce expression lines. 

The investment in Revox 7 is an investment in focused, science-backed skincare that delivers on its promises, which makes it a valuable addition to any anti-aging routine.

Key ingredients

  • Palmitoyl Hexapeptide-19 – helps relax facial muscles, which can reduce the appearance of wrinkles and fine lines.
  • Acetyl Hexapeptide-8 or Argireline – works similarly to Botox, it inhibits the release of neurotransmitters that cause muscle contractions. This can help reduce the appearance of wrinkles around the eyes, forehead, and mouth.
  • Acetyl Octapeptide-3 and Dipeptide Diaminobutyroyl Benzylamide Diacetate – These peptides stimulate collagen production and improve skin elasticity. This can help reduce wrinkles and fine lines, as well as firm and tighten the skin.

3. SkinMedica TNS Advanced+ Serum

SkinMedica TNS Advanced+ Serum is a groundbreaking product that stands at the forefront of anti-aging skincare technology. 

It blends growth factors, peptides, and antioxidants into a potent serum designed to transform the appearance of your skin. 

Ideal for those committed to an advanced skincare routine, this serum promises to reduce the visibility of fine lines and wrinkles while improving skin tone and texture, delivering significant and visible results over time.

Good forNot for
• Anyone seeking to significantly up the ante on their anti-aging regimen.

• It’s especially beneficial for those with mature or aging skin looking to invest in a product that offers comprehensive age-defying benefits and can help restore a more youthful, radiant appearance.
• Individuals working with a tight budget. Given its premium formulation and advanced ingredients, the TNS Advanced+ Serum comes with a higher price tag.

• However, for those who view skincare as an investment in their long-term appearance and well-being, its price reflects its high efficacy and cutting-edge formulation.

Why should you buy it?

The inclusion of growth factors is a game-changer, offering one of the most effective ways to improve the appearance of skin aging. 

Combined with peptides and antioxidants, the serum works synergistically to rejuvenate the skin at a cellular level, making it a potent weapon against the visible signs of aging.

Key ingredients

  • TNS-MR – a proprietary blend by SkinMedica. It contains a mix of growth factors, cytokines, and matrix proteins. 
  • Renessensce (RSC) Advanced – another proprietary blend containing botanicals, peptides, and marine extracts.

4. Drunk Elephant Protini Powerpeptide Resurf Serum 

Drunk Elephant’s Protini Powerpeptide Resurf Serum is a dynamic fusion of rejuvenating peptides, lactic acid, and amino acids designed to revitalize and strengthen your skin. 

This potent serum harnesses the power of advanced skincare ingredients to enhance skin texture, promote a more even skin tone, and deliver a youthful glow. 

Its formula is a testament to Drunk Elephant’s commitment to innovation, offering a product that aims to resurface and fortify the skin’s appearance without the use of harsh chemicals.

Good forNot for
• Those searching for a potent serum that addresses texture irregularities, uneven skin tone, and signs of aging. 

• It’s especially suited for individuals with combination, oily, or normal skin types looking to introduce a powerful boost to their skincare routine.
• Individuals with extremely sensitive skin. Because of its potent formula, this serum should be approached cautiously.

• Perform a patch test or consult your dermatologist to determine whether it suits your skin type.

Why should you buy it?

The combination of a high concentration of peptides with lactic acid makes this serum a powerful tool for resurfacing and strengthening the skin. 

It targets the key concerns of those looking to improve their skin’s overall texture and resilience, making it a worthwhile investment for noticeable results.

Key ingredients

  • Alpha Hydroxy Acid (AHA) – gently removes dead skin cells, promoting smoother texture, improved radiance, and potentially minimizing the appearance of pores.
  • Various types of signal peptides – These are messenger molecules that signal the skin to perform specific functions like collagen production, cell renewal, and improved elasticity. The serum contains a high concentration (11 peptides) targeting different areas.
  • Hyaluronic acid – This humectant ingredient attracts and retains moisture in the skin, keeping it plump and hydrated.
  • Squalane and plant oils (marula, green tea seed) – These lightweight oils provide moisture without feeling greasy and soothe the skin.
  • Amino acids – These are the building blocks of proteins and can contribute to skin repair and hydration [7].

5. Biossance Squalane + Copper Peptide Rapid Plumping Serum

Biossance Squalane + Copper Peptide Rapid Plumping Serum is an innovative skincare solution that combines the hydrating power of squalane with the rejuvenating effects of copper peptides. 

This serum is designed to deliver intense hydration, visibly plump the skin, and diminish the appearance of lines and wrinkles, offering a more youthful and radiant complexion.

Its formula is crafted to cater to dry, dehydrated, and aging skin needs, making it a vital addition to any skincare regimen focused on moisture and revitalization.

Good forNot for
• Anyone looking to address dryness, dehydration, and the visible signs of aging with a single product should consider this. 

• Its powerful hydrating and plumping effects make it an essential choice for those wishing to enhance their skin’s natural moisture barrier and improve overall skin health.
• Individuals with a known sensitivity to copper peptides should avoid this serum, as its copper peptide content could potentially trigger adverse reactions in sensitive skin.

Why should you buy it?

The combination of deep hydration from squalane, copper peptides’ skin-repairing effects, and hyaluronic acid’s moisture-retaining capabilities make this serum a powerhouse for combating dryness and aging signs. 

Its ability to visibly plump the skin and reduce the appearance of lines and wrinkles justifies the investment for those seeking noticeable improvements in skin texture and hydration.

Key ingredients

  • Hyaluronic acid – draws moisture to the skin and helps retain it, leaving skin feeling hydrated and plump.
  • Polyglutamic acid – more powerful than hyaluronic acid at attracting and holding onto water, further enhancing hydration [8].
  • Squalane – A plant-derived emollient that helps lock in hydration by forming a protective barrier on the skin’s surface, preventing moisture loss [9].

6. Charlotte’s Magic Serum Crystal Elixir

Charlotte’s Magic Serum Crystal Elixir captivates with its luxurious blend, promising not just a skincare product but a radiant, glowing experience. 

This serum is a concoction of expertly chosen peptides, vitamins, and polyglutamic acid, meticulously formulated to boost your skin’s natural radiance and provide an unparalleled glow. 

Its silky texture and potent ingredients work in harmony to rejuvenate the skin, leaving it feeling softer, smoother, and more youthful. 

Aimed at those who cherish their skin’s luminosity and vitality, this elixir is a testament to the magic of high-quality skincare.

Good forNot for
• Anyone yearning for that extra sparkle in their skincare routine. Whether your skin is looking a bit dull or you’re simply seeking to enhance its natural glow, this serum is your go-to. 

• It’s particularly effective for all skin types, from dry to oily, and everything in between, ensuring that anyone can achieve a radiant complexion.
• Those sensitive to fragrances in their skincare products might want to steer clear or proceed with caution, as this serum contains scent components that, while enchanting to some, may not be suitable for everyone.

Why should you buy it?

The blend of peptides, vitamins, and polyglutamic acid makes for a potent serum that addresses multiple skin concerns—from hydration to brightness and overall skin health. 

Investing in this serum means investing in a comprehensive approach to skincare, where luminosity, hydration, and rejuvenation are all achieved simultaneously.

Key ingredients

  • Polyglutamic acid – 4 times more effective than hyaluronic acid at attracting and retaining moisture, leaving skin plump and dewy.
  • Niacinamide – helps improve skin barrier function and contributes to better hydration.
  • REPLEXIUM® (a blend of peptides) – targets fine lines and wrinkles by potentially relaxing facial muscles and promoting a smoother appearance.
  • Golden Vitamin C – next-generation Vitamin C aims to brighten the complexion and skin tone.
  • Plant adaptogen extracts (First Light Snow Lotus & Resurrection Leaf) – botanical extracts may help the skin adapt to stress and environmental factors, potentially promoting a more radiant appearance.
  • Sepitonic M3 – may help energize the skin and improve its overall health.
  • Crystal Complex (Quartz, Amethyst, Ruby Powder) – while the exact benefits of these crushed gemstones are debatable, they might add a touch of radiance.

7. NeoStrata Cellular Restoration

NeoStrata Cellular Restoration is a potent anti-aging cream designed to rejuvenate the skin at a cellular level. 

Leveraging an advanced blend of peptides, antioxidants, and fruit stem cell extracts, this product aims to accelerate skin renewal, improve elasticity, and diminish the appearance of fine lines and wrinkles.

Its formula is crafted to support the skin’s natural repair processes, making it an essential tool for anyone looking to enhance their skin’s youthful appearance. 

With regular use, this cream promises to repair and protect the skin from future signs of aging.

Good forNot for
• Individuals noticing signs of aging and seeking a comprehensive solution to enhance skin rejuvenation. 

• It suits those who appreciate science-backed skincare formulations that deliver tangible results.
• Individuals with sensitive skin, given its potent active ingredients. 

• A patch test is advisable to ensure compatibility and avoid potential irritation.

Why should you buy it?

The cream’s multi-action formula targets several aging concerns simultaneously, offering value through its ability to improve skin texture, elasticity, and overall appearance. 

For those committed to an effective anti-aging skincare regimen, this product represents a sound investment in maintaining skin health and vitality.

Key ingredients

  • Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 – These peptides may stimulate collagen production and improve skin elasticity, making a firmer and more youthful appearance.
  • 5% Glycolic Acid (AHA) – gently removes dead skin cells, revealing a smoother texture, and brighter appearance and potentially minimizing pores.
  • 5% Gluconolactone (PHA) – offers similar benefits to glycolic acid but is gentler, making it suitable for more sensitive skin types. It may also stimulate collagen production.
  • 5% Maltobionic Acid (PHA) – aids in gentle exfoliation and may provide some antioxidant benefits.
  • Shea butter – provides rich moisture and helps soften the skin [10].
  • Glycerin – attracts and retains moisture in the skin, keeping it hydrated and plump.
  • Arginine – may help improve skin barrier function and contribute to overall skin health.
  • Grape seed extract – rich in antioxidants that help combat free radical damage, which can contribute to wrinkles and premature aging.
  • Vitamin E (Tocopheryl Acetate) – protects the skin from environmental damage and supports skin cell health.

Closing thoughts

Choosing the right peptide-infused skincare product can significantly impact your skin’s health and appearance. 

This guide has walked you through some of the top options available in 2024, each offering unique benefits tailored to different skin types and concerns. 

From hydration and plumping to anti-aging and texture improvement, these products embody the advancements in skincare technology. 

Remember, the key to maximizing their benefits lies in selecting a product that aligns with your skin needs. 

As you integrate these peptide powerhouses into your routine, expect noticeable improvements in your skin’s texture, tone, and overall radiance.

Photograph: Manuta/Envato

[1] https://www.outlookindia.com/whats-hot/10-best-face-serums-for-oily-skin-2023–news-336519
[2] https://www.potionorganic.com/blogs/news/peptides-101-the-ultimate-guide-to-understanding-and-using-them-in-your-skincare-routine
[3] https://www.hkvitals.com/blog/from-acne-to-wrinkles-how-peptides-can-improve-your-skin/
[4] https://sublimelife.in/blogs/sublime-stories/how-to-hydrate-your-skin-effectively-with-hyaluronic-acid
[5] https://www.healthline.com/health/beauty-skin-care/sodium-hyaluronate
[6] https://agelessaestheticsnj.com/understanding-hydrolyzed-hyaluronic-acid-skin-benefits/
[7] https://www.skintherapymaster.com/amino-acids-in-skincare
[8] https://www.biossance.com/blog/polyglutamic-acid/
[9] https://www.origins.com/ingredient-gallery/squalane
[10] https://health.clevelandclinic.org/shea-butter-benefits

The information included in this article is for informational purposes only. The purpose of this webpage is to promote broad consumer understanding and knowledge of various health topics. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.