7 Effective supplements if you have insulin resistance

In the modern world, millions of people are affected by insulin resistance, which has become a major health problem. 

The body’s cells become less receptive to the hormone insulin in this illness, which can cause difficulties and increased blood sugar levels.

Although food and exercise are important factors in treating insulin resistance, the strength of supplements in assisting this disease shouldn’t be undervalued.

The growing concern for insulin resistance

As obesity, sedentary behavior, and poor nutritional choices become more prevalent, insulin resistance is becoming more common. This illness can affect anybody, regardless of their metabolic status; it is not exclusive to those with diabetes. 

In addition to raising the chance of getting type 2 diabetes, insulin resistance also raises the risk of acquiring obesity, cardiovascular disease and hormonal abnormalities [1]. An integrated strategy combining lifestyle changes with targeted supplements has drawn much attention to address this rising problem. 

We may be able to increase insulin sensitivity, optimize glucose metabolism and support general metabolic health by including particular foods into our everyday routines.

The role of supplements in insulin resistance management

Instead of being seen as independent treatments for insulin resistance, supplements should be seen as complementary tools that increase the impact of lifestyle modifications.

While maintaining a healthy weight, exercising often and adopting a balanced diet are essential, supplements might offer further assistance by focusing on particular insulin resistance-related pathways.

The role of supplements in insulin resistance management

Some benefits of targeted supplementation are:

1. Improved insulin sensitivity

Certain supplements have been shown to improve insulin sensitivity, enabling cells to use glucose effectively and lowering the demand for excessive insulin synthesis.

2. Regulation of glucose metabolism

A more stable glycemic control may be maintained by consuming certain nutrients, which can help manage blood sugar levels and prevent spikes.

3. Reduction of inflammation

Insulin resistance is intimately related to chronic inflammation. Anti-inflammatory supplements can treat this illness and enhance metabolic health in general.

4. Antioxidant protection

The development of insulin resistance is influenced by oxidative stress. Antioxidant-rich supplements can reduce the negative effects of free radicals and improve insulin sensitivity.

People with insulin resistance may be able to maximize their results and gain better command over their metabolic health by adding certain nutrients into a thorough management strategy.

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7 effective supplements for insulin resistance

By including certain nutrients in our diet and supplement regimen, we can help control insulin resistance. These essential vitamins and minerals have efficiently enhanced insulin sensitivity, controlling glucose metabolism and lowering inflammation. 

Here are seven crucial vitamins for reducing insulin resistance:

1. Chromium

The metabolism of glucose depends heavily on the trace mineral chromium. By making it easier for insulin to attach to cells, it improves insulin’s function by encouraging glucose absorption from the circulation into cells. 

Chromium helps manage blood sugar levels and may assist those with insulin resistance to have better glycemic control by increasing insulin sensitivity [2]. It has also been linked to better lipid profiles and decreased cravings for carbs.

Depending on a person’s demands and medical circumstances, a different amount of chromium is advised daily. The usual dose range for adults is between 200 and 1000 micrograms (mcg) per day. It’s vital to remember that greater dosages should only be used when directed by a doctor.

Potential drug interactions with chromium supplements should be considered, especially those that may influence blood sugar levels. Before beginning chromium supplementation, those with diabetes or hypoglycemia should speak with their doctor to prevent side effects. 

To assure purity and effectiveness, selecting premium chromium supplements from reliable suppliers is important.

2. Magnesium

The mineral magnesium is essential for several physiological activities, such as insulin signaling and glucose metabolism. While magnesium insufficiency has been linked to insulin resistance, adequate magnesium levels are connected with increased insulin sensitivity [3]. 

Magnesium supplements may improve insulin activity and encourage improved glucose regulation in people with insulin resistance. Depending on factors including age, gender and certain medical problems, different magnesium intakes are advised daily. 

Adults’ recommended daily allowance (RDA) is between 270 and 320 milligrams (mg) for women and 310 to 420 mg for men. There are several magnesium supplements, including magnesium oxide, citrate, glycinate and others. 

The bioavailability and absorption rates of each type vary. For people with insulin resistance, magnesium citrate and glycinate may be recommended since they are often well-absorbed. 

To find the best dosage for a person’s requirements, start with a smaller amount and increase it gradually under medical supervision.

3. Alpha-lipoic acid

Strong antioxidant alpha-lipoic acid (ALA) works to shield cells from oxidative damage and inflammation. It increases glucose absorption into cells, promotes insulin sensitivity, and serves a special function in controlling insulin resistance. 

Additionally, ALA promotes mitochondrial health, essential for cells to produce energy. In those with insulin resistance or type 2 diabetes, studies have indicated that ALA supplements may improve glycemic management, reduce insulin resistance, and lower inflammatory indicators

Furthermore, it has been shown that ALA may help those with peripheral neuropathy, a typical consequence of diabetes [4]. The recommended daily intake of ALA for treating insulin resistance generally falls between 300 and 600 milligrams (mg). 

It is frequently advised to start with a smaller dose and raise it gradually to determine each person’s tolerance.

4. Berberine

A bioactive substance called berberine is present in several plants, including goldenseal, barberry and Oregon grape. It has been employed in conventional medicine for many years and is now well known for its capacity to reduce insulin resistance and encourage glucose regulation.

A major function in controlling cellular energy metabolism is played by the enzyme AMP-activated protein kinase (AMPK), which berberine activates. Berberine increases glucose absorption, enhances insulin sensitivity, and decreases glucose synthesis in the liver through activating AMPK. 

It also includes antioxidant and anti-inflammatory qualities, which add to its overall positive benefits [5]. The normal range of milligrams (mg) per day, split into many doses, for administering berberine for treating insulin resistance is 500 to 1500 mg. 

Under a healthcare practitioner’s guidance, starting with a smaller dosage and gradually increasing it is recommended.

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5. Cinnamon

A common spice called cinnamon is made from the bark of plants of the genus Cinnamomum. It includes bioactive substances, such as cinnamaldehyde, that can enhance insulin sensitivity and glycemic management.

According to studies, cinnamon may improve insulin signaling, encourage glucose absorption, and lessen insulin resistance. Additionally, it could aid in reducing fasting blood sugar levels and enhancing the post-meal glucose response. 

Cinnamon also possesses anti-inflammatory and antioxidant effects, which can help maintain metabolic health in general.

7 Effective supplements if you have insulin resistance

There is no set recommended dosage when it comes to using cinnamon supplements to treat insulin resistance. However, studies have demonstrated advantages with daily doses of cinnamon powder ranging from 1 to 6 grams (about 0.5 to 2 teaspoons). 

It is frequently advised to spread the dosage among smaller meals throughout the day.

Get top-notch goods from renowned manufacturers to assure purity and efficacy while selecting cinnamon supplements. Alternately, including cinnamon in the diet by dusting it on meals, putting it in drinks or cooking with it might be beneficial.

6. Fish oil

The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are particularly abundant in fish oil. For their numerous health advantages, including their possible function in controlling insulin resistance, these important fatty acids have been well-researched.

It has been demonstrated that omega-3 fatty acids have anti-inflammatory characteristics and lower systemic inflammation, frequently linked to insulin resistance and metabolic diseases [6]. Fish oil may assist in improving glycemic management and insulin sensitivity by lowering inflammation.

It is crucial to choose molecularly distilled and pure fish oil supplements when choosing fish oil supplements to make sure they are free of pollutants like heavy metals and PCBs (polychlorinated biphenyls). Select supplements that provide sufficient quantities of EPA and DHA in each serving.

The best fish oil dose depends on a person’s demands and medical situation. However, a daily dose of 1000–2000 mg of mixed EPA and DHA is frequently advised for general health advantages. 

Higher doses could be required for problems like insulin resistance, however, it is best to speak with a healthcare provider for specific advice.

7. Vitamin D

A vital component of many body processes, including immune system control, bone health, and cell development, vitamin D is a fat-soluble vitamin. Additionally, recent studies have raised the possibility of a connection between insulin resistance and vitamin D deficiency [7].

An increased risk of developing insulin resistance and type 2 diabetes has been linked to low vitamin D levels. By boosting the body’s responsiveness to insulin and supporting the healthy operation of beta cells in the pancreas, vitamin D is thought to affect insulin sensitivity. 

Blood sugar levels may be regulated and adequate vitamin D levels may support general metabolic health. Optimal vitamin D levels might vary, but generally speaking, blood levels of 25(OH)D (25(OH)D) of at least 30ng/mL are preferred. 

It is best to speak with a healthcare practitioner to receive individualized advice on vitamin D levels and supplements because individual needs may differ. Sunlight exposure and dietary sources including fatty fish, fortified dairy products, and egg yolks are two ways to get vitamin D. 

However, owing to insufficient sun exposure, certain geographic areas, or dietary limitations, many individuals may still suffer from vitamin D insufficiency. Supplementation may be advised in such circumstances.


Chromium, Magnesium, Alpha-Lipoic Acid, Berberine, Cinnamon, Fish Oil and Vitamin D are seven powerful supplements that can help manage insulin resistance. Each of these supplements offers distinct benefits and mechanisms of action in promoting insulin sensitivity, glucose metabolism and overall metabolic health.

Individuals with insulin resistance may take proactive measures to enhance glycemic control, lower their risk of problems, and empower themselves to greater health and well-being by combining the power of vitamins with good lifestyle choices.

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[1] https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-020-00558-9
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308119/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478262/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824456/
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111450/
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262608/
[7] https://www.ncbi.nlm.nih.gov/books/NBK56061/

Photograph: YuriArcursPeopleimages/Envato
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