8 Types of peptides for skin and how to use them

Are you frustrated with the many skincare options promising youthful skin yet delivering little results? You’re not alone.

While many people find traditional anti-aging products lacking, peptides offer a scientifically backed solution, gaining recognition for their efficacy.

This article explores eight types of peptides, each with unique properties to rejuvenate your skin.

From enhancing collagen production to fighting off free radicals, understand how incorporating suitable peptides into your skincare routine can significantly improve your skin’s health and appearance.

Let’s explore these potent ingredients and their optimal uses.

What are skincare peptides?

Peptides are short chains of amino acids, the building blocks of proteins, which are crucial for maintaining the structure and function of your skin. 

Unlike larger proteins like collagen, peptides are small enough to penetrate the skin’s upper layer, where they go to work by signaling your body to ramp up its reparative processes.

When applied through skincare products, peptides act as messengers encouraging your skin to boost collagen production [1], an essential protein that plumps the skin and reduces wrinkles. 

Some peptides also promote elastin synthesis, which improves skin elasticity and firmness [2]. This targeted communication helps your skin heal and rejuvenate more effectively, addressing common concerns like fine lines, sagging, and uneven texture.

Moreover, the versatility of peptides allows them to serve various functions in skin care. 

For example, carrier peptides deliver trace minerals to the skin to enhance wound healing and increase firmness [3]. In contrast, neurotransmitter-inhibiting peptides help relax facial muscles, thus smoothing dynamic wrinkles caused by repeated expressions [4].

By incorporating peptides into your skincare regimen, you’re essentially equipping your skin with the tools it needs to repair itself. 

The result is not just a temporary improvement in appearance but a healthier, more resilient skin barrier that can better withstand the effects of aging and environmental stressors.

What are the different types of peptides and their benefits?

Peptides are not only fundamental elements of your skin’s structure but also versatile skincare tools, each addressing different issues with precision. 

Here’s an in-depth look at eight peptide types and their benefits to your skincare routine.

1. Signal peptides

Signal peptides excel in communication with your skin cells, urging them to produce more collagen. This function is crucial, as collagen lends your skin youthful firmness and elasticity [5]. 

Regular use of products containing signal peptides can lead to noticeably enhanced collagen levels, making your skin appear more youthful and diminishing the appearance of wrinkles and fine lines. 

The result is a smoother, more resilient complexion that not only looks healthier but is better able to withstand the test of time and environmental challenges.

2. Carrier peptides

Carrier peptides perform a critical role by delivering essential minerals, such as copper, to your skin [6]. Copper is vital for various biological functions, including the healing of wounds and the production of collagen and elastin. 

By increasing the availability of copper, carrier peptides enhance your skin’s firmness and overall rejuvenation. 

Products containing these peptides are particularly beneficial for tired or aging skin, as they help restore the skin’s natural vigor and youthful radiance.

3. Neurotransmitter-inhibiting peptides

These peptides work by mimicking the natural mechanisms that relax muscles, similar to the effects of Botox but without invasive procedures. 

By inhibiting neurotransmitters that cause muscle contractions, these peptides reduce the formation and appearance of expression lines. 

Regular application can lead to a smoother complexion with fewer visible wrinkles, particularly around areas prone to expression lines like the eyes, forehead, and mouth.

4. Antimicrobial peptides

With their ability to fend off microbial invaders, antimicrobial peptides are essential for maintaining skin health and integrity [7]. 

These peptides provide a natural defense mechanism against bacteria, fungi, and viruses, reducing the risk of skin infections. 

This protective role is especially beneficial for acne-prone or sensitive skin types, as it helps prevent the conditions that lead to acne and other skin disturbances. 

By incorporating antimicrobial peptides into your skincare regimen, you can maintain a clearer, healthier complexion.

Photograph: LightFieldStudios/Envato

5. Enzyme-inhibitor peptides

These peptides target enzymes in your skin that degrade vital proteins like collagen and elastin, which are essential for maintaining the skin’s structure and elasticity [8]. 

By inhibiting these harmful enzymes, enzyme-inhibitor peptides help preserve the skin’s integrity, preventing sagging and wrinkles. 

Their action helps keep your skin firm and youthful, making these peptides valuable in anti-aging skincare products.

6. Brightening peptides

Brightening peptides tackle dullness and uneven pigmentation by combating inflammation and blocking the pathways that lead to excess melanin production. 

Additionally, they help to detoxify the skin, protecting it from pollution and minimizing the impact of environmental stressors. 

The result is a brighter, more even skin tone, with a visible reduction in dark spots and discolorations. 

These peptides are ideal for reviving the skin’s natural brightness and achieving a more luminous complexion.

7. Antioxidant peptides

Antioxidant peptides play a critical role in protecting the skin from oxidative stress caused by free radicals, which are unstable molecules that damage skin cells. This protection is crucial in preventing premature aging and maintaining healthy skin. 

By neutralizing free radicals, antioxidant peptides help prevent the breakdown of collagen and elastin, maintaining the skin’s youthful structure and preventing signs of aging such as wrinkles and laxity.

8. Argireline

Argireline, a synthetic peptide, is designed to mimic the natural mechanisms leading to muscle relaxation. 

Often referred to as a topical alternative to Botox, Argireline reduces the intensity and frequency of neurotransmitter release, thereby decreasing muscle movement. 

This reduction in muscle activity can significantly decrease the appearance of fine lines and wrinkles, particularly in areas of frequent movement like the forehead and around the eyes [9]. 

Ideal for those seeking non-invasive anti-aging treatments, Argireline offers a practical approach to maintaining smooth, youthful skin without the need for injections.

How many peptides are there?

The world of skincare peptides is vast, with over a hundred different peptides currently utilized in various formulations. 

Broadly categorized, these can be divided into signal peptides, carrier peptides, neurotransmitter inhibitors, antimicrobial peptides, and enzyme inhibitors, each designed to target specific skin concerns. 

Beyond the well-known types discussed previously, there are also collagen peptides, which specifically enhance the natural production of collagen, and hexapeptides, known for their ability to relax facial tension and reduce wrinkle depth. 

Another notable peptide is palmitoyl pentapeptide-4, commonly marketed under the trade name Matrixyl, renowned for stimulating collagen synthesis and repairing damaged skin [10]. 

What are the most effective peptides for the skin?

Scientific research points to several peptides known for their potent efficacy in skin care

Matrixyl, a peptide complex containing palmitoyl tetrapeptide-7 and palmitoyl oligopeptide, stands out for its ability to significantly boost collagen production, effectively reducing wrinkle depth and improving skin texture. 

Copper peptides are also highly regarded, with studies showing their dual ability to enhance skin regeneration and act as antioxidants [11]. 

Argireline is another powerhouse, especially for those seeking immediate effects in reducing fine lines. 

Additionally, the combination of signal and carrier peptides has been proven to enhance skin firmness and elasticity synergistically. 

Which is the best peptide for anti-aging?

When combating the signs of aging, certain peptides stand out for their targeted effectiveness. 

Argireline is particularly notable for its botox-like properties, reducing the appearance of expression lines by inhibiting muscle movement. 

Matrixyl 3000, a powerful peptide blend of palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, stimulates collagen and elastin production, which is crucial for maintaining youthful skin elasticity and reducing wrinkles. 

Additionally, copper peptides are revered for enhancing skin regeneration and firmness, providing a dual approach to aging by improving skin structure and resilience. 

These peptides are extensively researched and celebrated for delivering tangible anti-aging benefits, making them top recommendations for anyone looking to preserve a youthful complexion.

Can peptides be used every day?
Photograph: Prostock-studio/Envato

Can peptides be used every day?

Peptides are suitable for daily use and can be valuable to your skincare routine. Their gentle nature allows for regular application, typically without risk of irritation, making them ideal for various skin types, including sensitive skin.

Start with a peptide-rich serum or moisturizer to integrate peptides into your daily skincare regimen. 

Apply these products after cleansing and toning, ensuring your skin is clean and ready to absorb their benefits. 

For best results, use peptides in conjunction with a broad-spectrum sunscreen during the day, as this will protect your skin from UV damage while the peptides work to repair and rejuvenate your skin.

Also, layering different peptide product types to address multiple skin concerns should be considered. 

For instance, a serum with Argireline can be used in the morning to target expression lines. At the same time, a night cream containing Matrixyl might be applied in the evening to promote collagen production overnight. 

This strategic use of various peptides ensures comprehensive skincare coverage, maximizing the anti-aging and skin-healing effects day and night.

What not to mix with peptides?

While peptides are versatile and beneficial in skincare, certain ingredients might interfere with their functionality, diminishing their effectiveness. 

Avoid mixing peptides with strong acids, such as glycolic or salicylic acid [12]. These acids can alter the skin’s pH balance, potentially reducing the efficacy of peptides by breaking them down before they can be absorbed and perform their functions.

Another ingredient to use cautiously with peptides is vitamin C, especially in its pure form, ascorbic acid. 

The high acidity of vitamin C can clash with the peptide structure, leading to decreased stability and effectiveness of both ingredients when used simultaneously.

To create an effective skincare regimen, apply peptides as part of your base layer—after cleansing and toning but before heavier products like moisturizers and oils. 

If you use products containing conflicting ingredients, consider using them at different times of the day; for example, peptides can be applied in the morning, while acids or vitamin C can be used in your evening routine. 

This approach allows each ingredient to work effectively without interference, ensuring optimal benefits for your skin.

What can you pair with peptides?

When selecting complementary skincare products to enhance the effectiveness of peptides, consider incorporating hydrating agents like hyaluronic acid, ceramides, and niacinamide. 

Hyaluronic acid, a moisture-binding ingredient, plumps the skin and reduces wrinkles and fine lines, thus maximizing the collagen-stimulating effects of peptides. 

This combination ensures your skin remains hydrated and supple, providing an ideal environment for peptide absorption and function.

Similarly, ceramides are lipid molecules that are crucial in strengthening the skin barrier and retaining moisture. 

Pairing peptides with ceramides supports skin barrier restoration, particularly beneficial when using peptides that enhance skin firmness and structure, such as carrier and signal peptides.

Adding niacinamide, or vitamin B3, to this mix brings further benefits, enhancing the skin’s repair process and boosting the overall efficacy of peptide formulations. 

Niacinamide improves skin elasticity, increases ceramide levels, and helps reduce redness and blotchiness. 

This combination improves skin texture and tone and fortifies its resilience against environmental stressors and aging.

Closing thoughts

Understanding and utilizing peptides in your skincare routine can significantly enhance skin health and appearance. 

From boosting collagen production with signal peptides to smoothing wrinkles with neurotransmitter-inhibiting peptides, each type offers specific benefits tailored to various skin concerns. 

By incorporating peptides daily, you equip your skin with essential tools for rejuvenation and protection against aging. 

Remember, the right peptide selection and correct product combinations are crucial for achieving the best results. 

Carefully chosen, peptides can transform your skincare regimen, leading to a visibly healthier and more youthful complexion.


Can I use peptides with niacinamide?

Yes, you can use peptides with niacinamide, as they complement each other well. Together, they boost skin repair and enhance barrier function without interfering with each other’s properties.

Do peptides in skincare really work?

Yes, peptides in skincare are effective. They promote collagen production and skin repair, improving elasticity, reducing wrinkles, and enhancing overall skin health when used consistently.

What are the most commonly used peptides?

The most commonly used peptides include Matrixyl (palmitoyl pentapeptide), Argireline (acetyl hexapeptide), and Copper Peptides, known for their anti-aging, wrinkle-reducing, and skin-healing properties.

Is too much peptides bad for skin?

Using excessive peptides in skincare can lead to irritation and sensitivity, especially for those with delicate skin. It’s best to follow product instructions for optimal results.

[1] https://www.revivalabs.com/how-peptides-help-skin-the-power-of-peptides-to-unlock-a-youthful-glow
[2] https://edition.cnn.com/cnn-underscored/beauty/best-peptide-skin-care
[3] https://www.ulprospector.com/knowledge/4715/pcc-five-types-of-skin-repairing-peptides/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211334/
[5] https://pubmed.ncbi.nlm.nih.gov/34382523/
[6] https://www.cascadeeyeskin.com/blog/the-power-of-peptides-in-skincare/
[7] https://www.sciencedirect.com/science/article/pii/S0960982215014098
[8] https://colorescienceuk.com/blogs/news/peptides-what-they-are-and-what-they-can-do-for-your-skin
[9] https://biopelle.com/latest-blog-posts/argireline-key-skincare-ingredient-focus/
[10] https://www.dralpana.com/post/matrixyl
[11] https://cityskinclinic.com/benefits-copper-peptides-skin/
[12] https://www.skinceuticals.com.au/what-ingredients-to-mix-with-peptides.html

Photograph: LightFieldStudios/Envato
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