As we get older, time unfortunately begins to take its toll on our bodies. From having less energy to do the things you enjoy, to having more trouble sleeping, aging is a seemingly inevitable process that affects our whole bodies. Aging doesn’t however, have to impact our lifestyles. Mikra aims to solve the ‘aging problem’ with their new longevity supplement, CELLF, which targets oxidative stress and mitochondrial dysfunction – two main drivers of aging. CELLF is a different sort of supplement – one that has prevention, rather than cure, at its heart. It aims to prevent damage and delay biological aging before it starts, increasing the amount of healthy time people have left. So what is this new supplement, and does it actually work?
What is oxidative stress?
We all go through stress when trying to navigate busy modern life, and we all know how bad it can make us and our bodies feel. Our cells are also performing a thousand different functions to keep our bodies running. Cells undergo a certain type of stress, known as oxidative stress. This is caused by an imbalance between reactive oxygen species (ROS), also known as free radicals, and the antioxidants that neutralise them.
Free radicals are a natural by-product of many processes in the body. They can also be produced in response to environmental factors like toxins, diet, stress, and strenuous exercise. Luckily, our bodies neutralise free radicals using antioxidants. However, if the balance of free radicals and antioxidants is skewed, free radicals run rampant through the body causing oxidative stress that damages cells and tissues.
Understanding oxidative stress as a concept can be complicated; but its effects on the body are much clearer. Oxidative stress is associated with aging and a diverse range of age-related diseases . It is therefore a clear target for antiaging interventions like longevity supplements. The best defence against oxidative stress is by ensuring your body has the right amount of oxidative stress’ arch nemesis: antioxidants.
Antioxidants for antiaging
Free radicals cause oxidative stress that can lead to damage, disease and aging. As the body ages, it loses the ability to fight these free radicals, leading to greater oxidative stress and aging. This forms a vicious cycle.
Luckily, our bodies produce antioxidants to help stop free radicals in their tracks. Increasing our antioxidant levels, therefore, should reduce free radical and oxidative stress levels.
Antioxidants are commonly found in fruit and vegetables, and are part of the reason why these foods are so good for us. However, the bioavailability of natural antioxidants found in fruit and veg can be low. This is where supplements containing antioxidants come in.
For example, glutathione is the main antioxidant contained in Mikra’s CELLF supplements. It reduces dangerous free radicals produced by biological processes. Glutathione can also help stop free radicals from environmental factors like diet, stress and strenuous exercise. This in turn reduces oxidative stress in the body, protecting cells and preventing damage.
The longevity supplement scene
The longevity field is growing, with new research studies and biotech companies popping up all the time. Ironically, developing effective antiaging interventions takes time, during which we continue to age. Currently, all we can do to effectively slow aging and improve longevity is through lifestyle changes like getting enough sleep, exercising regularly and eating healthily.
One hack that longevity enthusiasts are turning to is longevity supplements. These combine scientific know-how from as esteemed places as the Buck Institute with the natural ingredients of neutraceuticals to improve health and, hopefully, longevity. Many longevity supplements use antioxidants to counteract oxidative stress and slow down aging.
The supplement scene is booming, with new supplements appearing every minute. Considering that the supplement market is less rigorously regulated than the pharmaceutical industry, how do you know what best to take? The key is to look at the ingredients.
- Contains a full spectrum 11-compound complex: nicotinamide riboside, quercetin, trans-resveratrol, L-theanine, fisetin, astragalus, TMG, spermidine, piperine, epigallocatechin gallate.
- Third-party tested for heavy metals, contaminants and potency.
- Made only with natural ingredients, non-GMO, GMP-certified.
What are CELLF supplements?
This is where the CELLF supplements come in. This is a special longevity supplements designed to combat the symptoms of oxidative stress at a cellular level. It may also delay your biological age, what age your body actually is, rather than what it says on your passport.
CELLF contains three key ingredients:
- Glutathione – a powerful antioxidant that reduces free radicals and reactive oxygen species within the body, protecting cells and preventing tissue damage.
- Coenzyme Q10 (ubiquinol) – improves the speed and efficiency of mitochondria for more energy production and availability at a cellular level.
- Pyrroloquinoline quinone – protects the brain. Also increases the number of mitochondria in your cells, improving cell function and resulting in more efficient, natural energy production.
This powerful trinity of ingredients is contained in a 10ml sachet of natural, vanilla flavoured gel. Crucially, the formula is free of caffeine, lactose, fillers, corn, wheat, soy, egg and GMOs.
One of the problems with supplements is that they aren’t properly optimized for absorption in the body. This prevents them from delivering the full range of nutrients they advertise. Without the proper protective coating, micronutrients can be broken down by the digestive system as they travel through your body, lessening their efficacy.
CELLF supplements avoid this problem by using protective technology to deliver its nutrients properly. Its active nutrients are protected by a double barrier for better transportation and absorption. Lactoferrin is combined with a liposomal barrier, forming an indestructible team that gets CELLF supplements through your gut without breaking down. It is then carried into your blood plasma and into your cells to do its job. This gives the ingredients in CELLF like the antioxidant glutathione better bioavailability than the natural antioxidants found in food.
Similarly to how oxidation can affect your cells through stress, exposure to oxygen during manufacturing can impair the power of supplements. To prevent this, Mikra use a special process to remove oxygen and retain efficacy of its CELLF supplements.
How do CELLF supplements work?
Now we know what CELLF supplements contain, we can understand how its ingredients work to reduce oxidative stress and free radicals. CELLF is a clinically-tested, dual-action supplement that targets two major drivers of aging: oxidative stress and mitochondrial dysfunction. So how do their active ingredients do this?
Better mitochondria for boosted energy
Both the coenzyme Q10 and pyrroloquinoline quinone contained in the supplement effect the mitochondria, famous from biology class as being the powerhouse of the cell. Mitochondria act like microscopic batteries, powering our movements as well as biological processes.
Unfortunately, with age, the number of mitochondria in our cells decrease, and they are more likely to stop functioning properly. This means there is less energy available, making us feel fatigued as well as slowing down the repair work our body does to the damage caused by aging. In fact, mitochondrial dysfunction is one of the nine hallmarks of aging.
CELLF works to restore the number and efficiency of our mitochondria even with age, meaning more energy is available to our cells and to us. Pyrroloquinoline quinone boosts the number of mitochondria within cells, therefore improving cell function and increasing natural energy production. Coenzyme Q10 on the other hand improves the speed and efficiency of mitochondria, also improving energy production on a cellular level.
- Fights the 3 main indicators of cellular aging: telomere shortening, ribosomal DNA shortening, and heterochromatin destabilization.
- Helps reduce inflammation caused by physical exertion and aging by blocking free radical and NF-kB protein receptors.
- Gluten-free, no added hormones, Halal.
Reducing the effects of oxidative stress
CELLF supplements also reduce oxidative stress and its diverse effects, namely inflammation, reduced energy levels, brain fog, disturbed sleep, and impaired physical recovery. We explain each of these symptoms of oxidative stress, their effects on the body, and how CELLF works to combat them.
A key pathway linking oxidative stress with ill health and aging is through inflammation. Inflammation is a natural, and usually helpful, response that the body uses to fight off infections. However, chronic inflammation in older people, known as inflammageing, can lead to chronic illnesses, frailty, and premature death. A major cause of inflammageing is oxidative stress caused by dysfunctional mitochondria . CELLF supplements work at a cellular level to combat oxidative stress and inflammation, as well as improving mitochondria dysfunction.
As you get older and your body starts to slow down, you may find that you have less energy than in your younger years. This can prevent you from doing your favourite activities, as well as getting enough exercise. We all know about the almost limitless benefits of exercise to health and longevity. Exercise is especially important as we age, as it is key to maintaining muscle mass and strength. Not having enough energy to exercise as you get older can accelerate the effects of aging even more, leading to nasty conditions like frailty and sarcopenia.
CELLF supplements act as a superfuel for when that cup of coffee just won’t cut it. CELLF boosts energy levels within your cells by improving the number and efficiency of the mitochondria. This gives you more energy to exercise as well as do what you love as you age, which in turn can help you to live longer since social engagement is linked to longevity.
One of the first signs of getting older is reduced mental clarity, loss of focus and forgetfulness. Collectively known as ‘brain fog’, these mild symptoms of neurological decline can make living well in old age a little more complicated.
The brain is a vastly complicated organ that controls many aspects of cognition including memory, decision-making, organisation, as well as housing our very personalities in its frontal lobe. Ironically, we know very little about the centre of knowledge that is the brain. What we do know is that the brain changes throughout our lives. The upside of aging is the accumulation of knowledge and experience in the brain that influence our understanding of the world. A downside of aging, however, is that our brains begin to slow down. Some common changes include forgetting names, difficulty multitasking, and reduced attention span .
This is a natural process, and one that is very different to more serious neurodegenerative conditions like Alzheimer’s and dementia. However, to live our best lives for longer, increased brain fog associated with aging is best prevented. Stress, lack of sleep, and vitamin and mineral deficiencies can all contribute to brain fog, so fixing these lifestyle habits can help. Taking CELLF supplements, which can protect neurons and improve cognition and focus over time, is also a good idea.
Sleep is one of the most accessible keys to better health and longevity as we age. Every night, we all fall into a resting state that repairs the damage to our bodies from the preceding day. Research has revealed that 7 hours a night is the optimal amount of sleep to promote healthy aging. Getting less than this, known as chronic sleep deprivation, has been linked to impaired cognitive performance, affecting processing speed, visual attention, memory and problem-solving skills. As we age, getting enough sleep can be more difficult to achieve. Sleep disruption has even been linked to conditions like Alzheimer’s.
Sleep and oxidative stress are closely linked; sleep is thought to help remove free radicals and oxidative stress accumulated during the day . Equally, sleep deprivation is thought to induce oxidative stress. Reducing oxidative stress with CELLF supplements, therefore, is thought to reduce poor sleep quality.
As we age, our muscle mass and strength declines. This, coupled with sedentary lifestyles common to the elderly, can lead to longevity-reducing conditions like frailty and sarcopenia. Oxidative stress can also lead to poor physical recovery, doubling this burden. Maintaining our physical prowess as we age is imperative, and regular exercise and eating enough protein can help.
Taking longevity supplements like CELLF is also beneficial. Considering that mitochondria produce energy to help us move, it is unsurprising that they are highly concentrated in our muscles. By improving the number and efficiency of our mitochondria, CELLF supplements can help supply more power to our muscles and boost physical recovery.
- Helps combat the effects of aging by promoting NAD+ production.
- Contains 250 mcg of copper (as Cu1, [cuprous nicotinic acid]).
- Vegan-friendly, gluten-free, and free from additives, fillers, and preservatives.