Does apigenin have negative side effects? What you should know

Apigenin, a naturally occurring compound in many plants, stands out for its potential health benefits [1].

You might have encountered it while looking for natural ways to boost your well-being. It’s in chamomile tea, a staple in bedtime routines for its calming effects, and in parsley, celery, and several other herbs and vegetables.

With the growing interest in natural supplements, apigenin has captured attention for its promising health benefits. Research highlights its anti-inflammatory, antioxidant, and even anti-cancer properties, making it an attractive option for those looking to enhance their health naturally.

However, as with any compound, understanding its full impact on our health is crucial. This includes being aware of any possible adverse side effects.

When you learn about these cons, you’ll be better positioned to decide whether apigenin is an excellent addition to your wellness routine. It’s all about finding what works best for you and your body, and part of that process is gathering all the necessary information.

What happens if you take too much apigenin?

Taking too much apigenin, especially in supplement form, can lead to several unwanted effects [2]. This could range from mild digestive discomfort to more serious interactions with medications.

When discussing natural compounds like apigenin, the conversation often leans heavily into their benefits. And why not? The prospect of boosting our health through what we consume is appealing. 

However, a truly informed choice comes from looking at the full picture, including potential side effects. So, let’s explore the less-talked-about side of apigenin: the precautions and side effects you should be aware of.

1. Digestive discomfort

Digestive discomfort is one such side effect that doesn’t get enough airtime. Suppose you’re diving into apigenin, known for its presence in calming teas and healthful veggies.

In that case, it’s worth noting that, particularly at higher doses, it might not sit well with everyone.

You might experience nausea, an upset stomach, or other digestive issues as your body reacts to this new addition. This doesn’t mean apigenin is a no-go; it’s more about finding the right balance that works for you. Here’s what you can do:

  • Start with small amounts and see how you feel.
  • Mix apigenin-rich foods into your diet rather than relying solely on supplements.
  • Stay hydrated and eat balanced meals to support your digestive health.

Listening to your body is key. If apigenin is causing discomfort, adjusting the amount you consume could make all the difference. Remember, the goal is to enhance your well-being, not to introduce new issues.

digestive discomfort

2. Interactions with medications

Navigating the landscape of dietary supplements and how they interact with medications can be tricky. Apigenin, while offering numerous health benefits, isn’t free from this complexity. It’s particularly important to understand how it might play along with medications you’re already taking.

Apigenin can affect the liver’s ability to process certain drugs, potentially leading to an increased risk of side effects or reduced effectiveness of your medication [3]. This is especially true for:

  • Blood thinners
  • Blood pressure medications
  • Some types of cancer treatments

Here’s how you can manage this risk:

  • Always talk to your healthcare provider before adding apigenin supplements to your regimen.
  • If you’re taking medication, ask about potential interactions.
  • Monitor your body’s response when starting a new supplement.

Knowledge is power when it comes to combining supplements with medications. Being open with your doctor about your supplement intake ensures you’re taking steps to support your health without unintended consequences.

3. Effects on hormone-sensitive conditions

Apigenin’s impact on hormone-sensitive conditions is a crucial aspect to consider, especially for those with health issues like breast cancer or endometriosis.

This natural compound, found in various plants and herbs, can mimic estrogen, a hormone that plays a pivotal role in these conditions. Here’s what you need to know:

  • Apigenin may influence the body’s estrogen behavior.
  • For those with conditions like breast cancer, endometriosis, or other hormone-sensitive issues, it’s important to approach apigenin with caution.

To navigate this safely, you might need to:

  • Consult with a healthcare provider before integrating apigenin into your diet or supplement routine.
  • Monitor any changes in your condition or symptoms closely.
  • Discuss with your doctor the potential need to adjust apigenin intake based on your health status.

Understanding how apigenin interacts with your body’s hormonal balance helps ensure that your approach to incorporating this compound supports your health goals without adverse effects.

How much apigenin can you take?

Navigating the world of supplements can often lead to questions about dosage—how much is just right?

When it comes to apigenin, finding the optimal amount for your body is key to harnessing its benefits without overstepping into discomfort or potential side effects.

Generally, doses in studies vary from 50 to 600 mg per day [4], but starting at the lower end of this range and adjusting based on your personal response and health needs is advised. 

Whether you’re turning to this naturally occurring compound for its potential anti-inflammatory, antioxidant, or even anti-cancer properties, understanding how much to take—and how often—is essential for reaping the benefits without unwanted side effects.

Starting point

This natural compound, found in many plants, is celebrated for its potential health benefits, including its anti-inflammatory and antioxidant properties.

Whether you’re considering apigenin for these benefits or its role in potentially supporting cancer prevention, the foundation of your journey begins with knowledge and choice.

Look into natural sources like chamomile tea, parsley, and celery for a gentle introduction. Consider your current health status and any medications you’re taking. Think about your diet and lifestyle to see where apigenin could fit in seamlessly.

Taking these steps helps ensure that your introduction to apigenin is informed, balanced, and tailored to your unique health profile and goals.

Dosage guidelines

Navigating the right dosage of apigenin can make all the difference in how you benefit from this natural compound. Since it’s found in both foods and supplements, understanding how much to take is crucial.

  • For food sources: Enjoying foods rich in apigenin, like chamomile tea, parsley, and celery, as part of your daily diet doesn’t usually require strict dosage considerations [5]. These provide moderate amounts of apigenin that are generally safe for everyone.
  • For supplements: When it comes to supplements, starting with a lower dose is wise. Research suggests dosages ranging from 50 to 600 mg per day, but starting at the lower end of this scale and observing how your body reacts is key. Always consult with a healthcare professional before beginning any new supplement to ensure it aligns with your health needs and current medications.

The aim is to enhance wellness without overstepping what your body comfortably handles. Listening to your body and seeking professional advice are your best guides.

Tips for starting

Starting with apigenin, whether through diet or supplements, can be a great addition to your health routine. Here are some tips to make this introduction as smooth as possible:

  • Before diving into supplements, a chat with your doctor can provide personalized advice based on your health history.
  • Especially with supplements, it’s smart to start small. Observe how your body reacts before considering any increase.
  • Add apigenin-rich foods like chamomile tea, parsley, and celery into your meals. This natural approach offers balanced benefits.
  • Keep an eye on how you feel after introducing apigenin. Any adverse effects should prompt a reassessment of your approach.
  • Keep researching and learning about apigenin. Understanding its effects helps you make informed decisions about your intake.

By following these steps, you can explore the benefits of apigenin confidently, ensuring it fits well within your lifestyle and wellness goals.

Adjusting your dosage

Finding the right dosage of apigenin that works for you may require some adjustments along the way. Here’s how to fine-tune your intake:

  • Pay attention to how you feel after consuming apigenin. Signs of discomfort may indicate the need to adjust your dosage.
  • If you decide to change your dosage, do so gradually. This helps your body adapt and allows you to monitor the effects of each adjustment.
  • Keep your doctor in the loop about any changes, especially if you manage health conditions or take other medications.
  • Keeping a journal of your apigenin intake, including doses and any side effects, can be incredibly helpful for tracking what works best for you.

Adjusting your dosage isn’t just about finding the right amount; it’s about ensuring that apigenin complements your health and wellness journey effectively and safely.

Is it safe to take apigenin everyday?

Is it safe to take apigenin everyday?

Incorporating apigenin into your daily routine sparks an important question about safety and regular consumption. Yes, it is generally safe to take apigenin every day [4], especially when consumed through dietary sources like chamomile tea, parsley, and celery.

However, if you’re considering higher doses through supplements, consulting with a healthcare professional is crucial to ensure it aligns with your individual health needs and doesn’t interfere with any medications you may be taking.

Including apigenin in your diet safely is all about balance and being mindful of your body’s reactions. Here’s a straightforward way to do it:

  • Diversify your sources: Incorporate a variety of apigenin-rich foods like chamomile tea, parsley, celery, and artichokes into your diet. This not only ensures a balanced intake of apigenin but also other nutrients.
  • Listen to your body: Notice how you feel after consuming these foods. If you experience any discomfort, consider adjusting the amounts.
  • Consult with a healthcare professional: Especially if you have existing health conditions or are on medication, a quick chat with your doctor can provide guidance tailored to your health needs.
  • Consider your overall diet: Apigenin-rich foods should complement a balanced diet. Ensure you’re also getting plenty of fruits, vegetables, whole grains, and lean proteins.

By following these tips, you can enjoy the benefits of apigenin without worry, making it a beneficial part of your wellness journey.

Closing thoughts

Understanding apigenin and its potential effects on our health is just the beginning. Whether you’re drawn to its anti-inflammatory properties, interested in its antioxidant benefits, or curious about its role in cancer prevention, the key is to approach its inclusion in your lifestyle with mindfulness and informed caution.

As we wrap up, we encourage you to take these insights and apply them to your journey towards wellness. If apigenin sounds like a good fit for you, take the first step by integrating it into your diet through natural sources or discussing supplement options with a healthcare provider.


What are the effects of apigenin?

Apigenin is known for its anti-inflammatory, antioxidant, and potential anti-cancer properties. It can support overall health by mitigating oxidative stress and reducing inflammation in the body.

Is it safe to take apigenin every day?

Yes, consuming apigenin daily, especially from natural food sources, is generally safe for most people. If you’re using supplements, it’s wise to consult a healthcare professional to ensure they fit your health profile.

Is apigenin toxic?

Apigenin is not considered toxic when consumed in amounts typically found in food. However, like any supplement, excessive intake can lead to side effects, so moderation is key.

What precautions are required for apigenin?

It’s important to consider potential interactions with medications and their effect on hormone-sensitive conditions. Always consult with a healthcare provider before adding apigenin supplements to your routine, especially if you have existing health conditions or are on medication.


Photograph: rezkrr/Envato Elements
The information included in this article is for informational purposes only. The purpose of this webpage is to promote broad consumer understanding and knowledge of various health topics. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.