Want to improve your healthspan and aim for longer, fitter life, but don’t know where to begin? With various vitamin and supplement products on the market promoting healthspan and longevity, it can be tricky to work out which one is right for you…
Enter Hello100, a new supplement that combines five fantastic ingredients to help you take control of your biological aging synergistically.
The key ingredient in Hello100 is NMN (nicotinamide mononucleotide), a small molecule that has a big role to play, as we shall see.
NMN and NAD+
NMN is a precursor of NAD+ (nicotinamide adenine dinucleotide), an essential co-enzyme that is involved in various critical cell functions, including cell growth and repair, metabolism, DNA repair, and survival.
NAD+ plays a crucial role in the process of cellular respiration, which is the process by which cells convert glucose and oxygen into energy. NAD is also involved in the regulation of gene expression, the process by which our genetic information is used to make amino acids, the building blocks of life.
An organism cannot survive without NAD+. The sirtuins, which repair damaged DNA, are among the proteins that use NAD+ throughout the body, and it is also crucial for mitochondria, which are the cell’s powerhouses and produce the chemical energy that our bodies use.
So, why not just grab a bottle of NAD+ supplement off the shelves, if you’re looking for a supplement? Well, NAD+ is not absorbed well by the digestive system, and nor is it directly taken up by cells – these add up to not making it a particularly good supplement. Instead, it is better to take a precursor – one of the key building blocks – that your body can use to make the vital NAD+.
Cells and tissues consume a great deal of NAD+, generating the byproduct NAM. The body uses NAMNNM to convert NAD back into NAD+ and the cycle begins again – this vital process is called the salvage pathway. This is why it is crucial to have NMN available to keep the salvage pathway performing at optimum levels.
Sadly, NAD+ levels decline with age, and reduced levels of NAD+ mean less energy available for repair and renewal – this contributes to aging and leads to various age-associated diseases. Supplementing with NMN can increase NAD+ levels in the body, slowing or reversing the aging process and preventing age-associated diseases.
NAD+ and mitochondrial health
Our mitochondria produce cellular energy through metabolic processes such as glycolysis, the TCA cycle (also known as the Krebs cycle or Citric Acid cycle), and the electron transport chain.
In addition to binding to enzymes, NAD+ carries electrons between molecules. In the same way that a battery recharges by transferring electrons from one molecule to another, NAD+ transfers electrons within cells.
When electrons are expended to provide energy, the battery gets depleted and without a boost, those electrons cannot return to their starting point. In cells, NAD+ serves as that booster. As a result, NAD+ can decrease or increase enzyme activity, gene expression, and cell signaling.
Take control of your biological aging with Hello100. Click here to learn more.
NAD+ and DNA damage control
In the course of aging, organisms accumulate DNA damage due to factors such as pollution, radiation, and imprecise replication of DNA. DNA damage is believed to be the leading cause of aging according to the current aging theory.
The ‘molecular machinery’ to repair this damage can be found in almost all cells and the machinery consumes NAD+ and energy molecules. Due to this, excessive DNA damage can drain the resources of the cell.
Poly (ADP-ribose) polymerase (PARP) is one of the main enzymes dependent on the NAD+ level and involved in DNA repair . As DNA damage accumulates with age, PARP levels increase, decreasing NAD+ concentration as a result. This depletion is further exacerbated by any further DNA damage in the mitochondria.
Can researchers design a combination of NMN and other compounds to target specific diseases?
Focusing on cardiovascular diseases with NMN and resveratrol may be a good option if raising NAD+ levels is genuinely effective for treating age-related diseases. The same supplement combination may also alleviate musculoskeletal disorders like frailty.
Moreover, increasing NAD+ levels with NMN and resveratrol may counteract age-related lung diseases, such as lung fibrosis in individuals who smoke. According to other research, smoking induces lung tissue fibrosis, which can be alleviated by boosting NAD+ levels, so targeting this disease with NMN in combination with resveratrol and other supplements and vitamins may improve lung health . Before making any conclusions, further studies using mouse models for these disorders and clinical trials are required.
In this study, NAD+ levels in the brain were reduced six hours after NMN with resveratrol or ginsenosides was taken. The duration of this effect needs to be studied over longer periods.
In the case of these supplement combinations, NAD+ levels in the brain may drop for extended periods, resulting in a tradeoff between increasing NAD+ levels in the heart, skeletal muscle, and lung tissue. Furthermore, the mice used in the study were quite young (six to eight weeks old). To determine whether the combination of these supplements increases NAD+ in certain organs across different age groups, experiments will need to be conducted on mice of different ages .
5-in-1 NMN supplement
NMN has fantastic benefits, including its ability to increase NAD+ and repair DNA cells, increase energy levels, sharpen your mind and improve muscle tone and endurance. What is the best way to take this supplement?
When taken orally, NMN is subjected to harsh conditions in the gastrointestinal tract, reducing its stability and bioavailability. Moreover, non-liposomal supplements have reduced cellular uptake.
Bioavailability is the amount of substance that enters your bloodstream to get the health benefits you’re looking for. In regular capsules, most NMN will not reach the bloodstream.
With the options available in the market today, some individuals may choose pure NMN supplements and, in most cases, powder – introducing a 5-in-1 holistic solution in pill form to address this concern with Hello100 NMN.
The synergy of these four ingredients is essential for methylation, which is a crucial step in NMN conversion into NAD+. While resveratrol enhances the activation of sirtuins needed for DNA repair, TMG, Folate, and Vitamin B12 participate in methylation.
Looking into Hello100’s 5-in-1 ingredient list and the known benefits of NAD+, here’s how they contribute to your longevity:
Niacinamide mononucleotide (NMN) is a molecule that plays a role in the biosynthesis of NAD (nicotinamide adenine dinucleotide). NAD is a coenzyme that is found in all living cells and is involved in a wide variety of metabolic processes, including energy production, DNA repair, and gene expression.
NMN is a derivative of niacin (vitamin B3) and is converted into NAD by enzymes in the body. Taking NMN as a supplement is thought to boost levels of NAD and potentially improve various aspects of health and well-being, such as energy metabolism, cellular repair, and aging.
Liposomal NMN is a form of NMN that has been encapsulated in tiny bubbles called liposomes. Liposomes are made from phospholipids, which are the same types of molecules that make up cell membranes. By encasing NMN in liposomes, this important molecule is shielded from the highly acidic environment in the stomach, preventing the destruction of the compounds; additionally, due to its similar structure to the cell membrane, the liposome can bind to the cell, delivering the supplement molecules directly into the cell, keeping the ingredients in the capsule intact.
Betaine, which is also called trimethylglycine (TMG), is a source of methyl groups; betaine is known as a methyl donor (in fact, it has three methyl groups), a molecule that plays a key role in the conversion of NMN to NAD+.
The convertion of NMN requires methyl groups, but they are important for another reason.
Methyl donors play a significant antiaging role; essential for normal development, DNA methylation is involved in several key processes and is an epigenetic mechanism, meaning it sits on top of DNA. DNA methylation is used by cells to control gene expression as by methylating DNA (or specific genes), genes can be switched off.
However, as we age, parts of our DNA become too little methylated, and genes that should be switched off become active; this allows rogue elements in our DNA to multiply, causing dangerous mutations and inflammation. These are good reasons to make sure you onboard enough methyl donors!
Trans-resveratrol: is a compound found in certain plants, such as grapes and berries, that has been shown to have antioxidant and anti-inflammatory properties. It is also known to have a positive effect on the aging process by activating the sirtuin enzymes in the body, which play a role in regulating cellular metabolism. In connection with NAD (nicotinamide adenine dinucleotide), trans-resveratrol has been found to increase levels of NAD in the body. Additionally, Trans-resveratrol has also been found to have a beneficial effect on the overall NAD+/NADH ratio in the body. This ratio plays a crucial role in many cellular processes, including DNA repair, energy production, and cell signaling. A healthy NAD+/NADH ratio is associated with better overall health and longevity.
Vitamin B12: plays a critical role in the production of NAD, which is an essential coenzyme that is involved in various metabolic processes in the body. Without enough vitamin B12, the body is unable to produce enough NAD, which can lead to various health problems.
Folate: also known as vitamin B9, is a water-soluble vitamin that is important for a variety of bodily functions. One of its key roles is in the process of DNA synthesis, which is necessary for the production of new cells. Additionally, folate plays a crucial role in the metabolism of homocysteine, an amino acid that can be harmful to the body in high concentrations.
The synergy of Hello100 ingredients that promote healthspan
Hello100 5-in-1 NMN formula is designed to help you live longer and maintain stable health. The 5 ingredients in each capsule complement one another to maximize your healthspan.
Increase your cellular energy metabolism adn control age related aging with Hello100. Click here to shop Hello100.
NMN And Betaine’s relationship
The supplement betaine, commonly known as TMG, is obtained from beetroot and is essential for liver function, cellular reproduction, and heart health.
How did TMG end up in the Hello100 NMN capsule? Consider methyl groups as a pool of molecules sacrificing themselves to defend genetic information. This may result in an empty pool. However, TMG is here to fill it up with methyl molecules to maintain its sustainable activity.
Vitamin B12 and Folate relationship
Folate is the active form of folic acid, while cobalamin is vitamin B12. It is essential to consume vitamin B12 and folate to produce DNA and red blood cells. Additionally, they facilitate the transfer of methyl groups and are methyl donors.
The role of Folate and Vitamin B12 in DNA and protein methylation is one of their many crucial functions. In simple terms, methylation refers to chemical modifications to proteins and DNA strands that protect genetic information and support healthy development.
DNA and protein methylation regulates gene expression turning on and off healthy or weak genes, respectively. According to studies, DNA methylation changes or inactivity may lead to cardiovascular, neurological, and autoimmune system disorders and cancer. Moreover, methyl donor deficiency may lead to poor DNA methylation and DNA mutations.
Trans-resveratrol and NMN relationship
Trans-resveratrol is the more active form of resveratrol, which is commonly found in resveratrol supplements. Resveratrol is difficult for the human body to absorb and use, and most of it is passed through the urine. However, trans-resveratrol is more readily absorbed.
Resveratrol is a naturally occurring polyphenol. Antioxidants, such as polyphenols, protect the body from inflammation and damage. Grapes, grape seeds, red wine, cocoa, blueberries, cranberries, and peanuts contain resveratrol.
The life science company strived to verify the unique Hello100 formula by gauging its impact on NAD+ levels and longevity genes’ expressions. One of their goals is to deliver a product that works well, as seen in a Hello100 case study.
NMN’s bioavailability has been enhanced by Hello100’s unique, holistic delivery system. The pill uses liposomal technology (for bioavailability) as well as other active ingredients like Betaine (TMG) for methylation.
By increasing cellular uptake, liposomes dramatically improve product delivery. Upon binding to the cell membrane, it releases its active ingredients. Additionally, NMN shielded in liposomes can pass through highly acidic gastrointestinal environments and stay intact.
Moreover, studies show the importance of bioavailability with low doses delivering no unwanted side effects. The Hello100 liposomal NMN formula was created in collaboration with scientists, molecular regenerative medicine experts and biohackers.
Hello100’s NMN ingredients were carefully selected to contribute to increasing NAD levels and longevity genes. The liposomal technology chosen for Hello100 liposomal NMN enhances cellular uptake while protecting the ingredients in the gastrointestinal tract from harsh conditions.