Is berberine safe for your heart? What you need to know

Heart health is a topic that hits close to home for many of us. After all, our hearts are the engines that keep us going, pumping life through our veins day in and day out. 

When it comes to finding ways to support our heart health, it’s only natural to be curious about the latest trends and supplements making waves in the wellness industry – one of which is berberine. This natural compound is receiving considerable attention for its heart-health benefits. 

It’s cool because people have used berberine for centuries in traditional medicine, like Ayurveda and Chinese medicine. 

Today, modern science is catching up. Studies show berberine may help lower cholesterol, control blood sugar, and reduce inflammation—all important for a healthy heart.

Does berberine strengthen the heart?

Berberine can strengthen the heart. Research suggests that berberine improves heart health through several mechanisms. It helps lower bad cholesterol levels, regulates blood sugar, reduces inflammation, and supports healthy blood pressure.

These benefits collectively contribute to a stronger and healthier heart, making berberine a promising supplement for cardiovascular support.

Let’s explore berberine’s potential for supporting heart health. Discover how this natural compound may help regulate cholesterol levels, reduce inflammation [1], and improve overall cardiovascular function. 

Cholesterol levels

Studies suggest it can help lower LDL (bad) cholesterol while increasing HDL (good) cholesterol, creating a more favorable lipid profile. 

By modulating cholesterol levels, berberine can lower the risk of cardiovascular conditions, including heart attacks and strokes. Its capacity to encourage a more favorable cholesterol ratio highlights its potential as a natural supplement to support heart health.

But it’s crucial to remember that everyone reacts differently to berberine, so it’s best to speak with a doctor before using it regularly, especially if you have a history of heart problems or are taking any drugs that may raise your cholesterol.

blood sugar regulation
Photograph: ThamKC/Envato

Blood sugar regulation

Berberine has been studied for its potential to regulate blood sugar levels effectively. Research suggests that it may improve insulin sensitivity and enhance glucose metabolism, leading to better control of blood sugar levels. 

By promoting balanced blood sugar levels, berberine could reduce the risk of diabetes-related complications, including cardiovascular issues. 

Its ability to support blood sugar regulation highlights its value as a natural supplement for individuals looking to manage their diabetes or prevent its onset [2].

However, it’s essential to approach berberine with caution, especially for those already taking medications to manage blood sugar levels, as interactions may occur. 

Anti-inflammatory properties

Chronic inflammation is a major factor in several cardiovascular disorders because it can damage blood vessels and cause atherosclerosis.

Berberine helps reduce inflammation by inhibiting pro-inflammatory cytokines and pathways, potentially lowering the risk of heart-related issues. 

Its anti-inflammatory effects extend beyond heart health, offering benefits for overall well-being by addressing inflammation-related conditions such as arthritis and metabolic syndrome. 

While promising, it’s crucial to use berberine under the guidance of a healthcare professional, especially if you have existing health conditions or are on medications that affect inflammation. 

Understanding its potential interactions and appropriate dosages can help maximize its benefits while ensuring safety.

Blood pressure

Lowering blood pressure helps reduce the risk of heart attacks, strokes, and other cardiovascular problems. Berberine’s potential to support healthy blood pressure levels makes it a valuable supplement for those looking to improve their heart health naturally. 

But before including berberine in your regimen, like with any supplement, it’s crucial to speak with a doctor, particularly if you currently use blood pressure medicine.

You can take berberine safely and efficiently if you are aware of the right dosage and any possible drug interactions.

Endothelial function

Berberine enhances endothelial function by increasing nitric oxide production, which helps relax and dilate blood vessels, improving circulation and reducing blood pressure. 

This improvement in endothelial health can contribute to better overall cardiovascular function and reduce the risk of heart disease. Berberine offers a natural way to promote heart health by supporting the endothelium. 

But as usual, it’s crucial to speak with a doctor before taking any new supplements, especially if you already have cardiovascular disease or are on other drugs. 

How safe is berberine for heart health?

Berberine has gained attention for its potential heart health benefits, but understanding its safety is crucial. A comprehensive study examined berberine’s impact on heart health [3], providing valuable insights.

The study indicates that berberine can significantly improve cardiovascular health by lowering cholesterol levels, regulating blood sugar, and reducing inflammation. 

It highlights berberine’s ability to enhance endothelial function, which is crucial for maintaining healthy blood vessels and preventing atherosclerosis.

Key findings

  • Cholesterol and blood sugar: Berberine helps reduce LDL cholesterol and blood sugar levels, which is crucial for heart health.
  • Anti-inflammatory properties: It helps lower inflammation, a risk factor for heart disease.
  • Endothelial function: Berberine improves the health of blood vessel linings, enhancing cardiovascular function.

While berberine shows promise, it’s essential to be aware of potential side effects. The study notes that berberine is generally well-tolerated at recommended dosages, but individual responses can vary.

Who should avoid berberine?

Berberine offers numerous potential health benefits, but it’s not suitable for everyone [4]. Certain individuals should avoid this supplement to prevent adverse effects and health complications.

Let’s identify those who should not take berberine to maintain optimal health and well-being.

Pregnant or breastfeeding women

Pregnant or breastfeeding women should avoid taking berberine due to a lack of research on its safety during these critical periods. 

Potential risks exist for both the mother and the baby, including possible complications during pregnancy and adverse effects on the infant. It’s best to err on caution without clear evidence supporting its safety. 


There is a potential for adverse reactions or interference with growth and development. Without sufficient studies confirming its safety and efficacy for children, using berberine poses unnecessary risks. 

Parents should consult a healthcare provider before giving their children supplements to ensure they receive safe and appropriate treatments. Prioritizing well-studied and pediatrician-recommended options is crucial for safeguarding children’s health.

Individuals with specific medical conditions

Individuals with certain medical conditions should avoid berberine due to potential risks and complications:

  • Liver disease: Berberine may worsen liver function, posing additional risks to those with pre-existing liver conditions [5].
  • Kidney disease: Impaired kidney function can lead to the accumulation of berberine, increasing the risk of toxicity.
  • Low blood pressure: Berberine’s blood pressure-lowering effects could be harmful for those with already low blood pressure.
  • Hormonal disorders: Conditions like hypothyroidism or polycystic ovary syndrome (PCOS) may be exacerbated by berberine’s influence on hormone levels.

Those undergoing surgery

Berberine should not be taken by anyone having surgery since it can interfere with blood coagulation and blood sugar levels.  This increases the risk of complications during and after the procedure. 

To ensure safety, discontinue berberine at least two weeks before any scheduled surgery. Always disclose to your healthcare professional any supplements you take to avoid any possible problems. 

People with hormonal disorders

People with hormonal disorders, such as hypothyroidism or polycystic ovary syndrome (PCOS), should avoid berberine. It can influence hormone levels, potentially worsening these conditions. 

Always prioritize safety and professional guidance when considering new supplements.

What is the best way to take berberine?

Using berberine safely involves understanding the right dosage, potential side effects, and interactions with other medications. Here’s how to incorporate this natural supplement into your routine while minimizing risks:

1. Start with a low dose

Begin with 500 to 1,000 mg daily, divided into two or three doses. This cautious approach reduces the possibility of adverse effects such as stomach problems.

Gradually increase the dosage if needed, but always follow your healthcare provider’s guidance. By starting small, you can monitor your body’s response and adjust accordingly, ensuring a safer and more effective use of berberine. 

This method also helps maintain stability and effectiveness in managing your health concerns.

2. Monitor for side effects

Monitoring for side effects while using berberine is crucial to ensure your safety and well-being. Keep an eye out for the following common side effects:

Digestive issues

  • Diarrhea
  • Constipation
  • Stomach cramps


  • Persistent or recurring headaches may occur, especially at higher doses.

Lowered blood pressure

  • Feeling dizzy or lightheaded, particularly if you are already on blood pressure medication.

Contact your healthcare provider immediately if you notice any of these side effects. They might adjust your dosage or recommend discontinuing the supplement. It is essential to track any new or worsening symptoms and discuss them with your doctor.

monitor side effects
Photograph: amenic181/Envato

3. Avoid certain combinations

When taking berberine, be mindful of potential interactions with other medications and substances. Combinations can have unfavorable effects or lessen the impact of your medications. Berberine shouldn’t be taken with:

  • Blood sugar-lowering medications: Medications like metformin may interact with berberine, leading to excessively low blood sugar levels.
  • Blood pressure medications: Berberine and antihypertensive medications together may create dangerously low blood pressure.
  • Anticoagulants or antiplatelet drugs: When combined with blood thinners, berberine may make bleeding more likely. 
  • Certain antibiotics: Some antibiotics may interact with berberine, affecting their efficacy or increasing side effects [6].

Before using berberine, always check with your doctor if you are on any of these drugs. They can guide safe use and potential alternatives, ensuring you avoid harmful interactions while reaping the benefits of berberine.

In closing

Berberine holds significant promise as a natural supplement for supporting heart health and managing various conditions. However, its use must be approached with caution and awareness of potential risks. 

Consulting with a healthcare provider is the first step to ensuring berberine is right for you, especially if you have existing health conditions or are on medication. These steps can help you safely and effectively integrate berberine into your wellness routine.

Berberine offers a compelling option for those looking to explore natural supplements, provided it’s used responsibly. Stay proactive about your health, consult professionals, and make choices that best support your well-being.


How does berberine benefit heart health?

Berberine helps lower LDL cholesterol and blood pressure, improving overall cardiovascular function. It also has anti-inflammatory properties that protect the heart.

Who should avoid taking berberine?

Pregnant or breastfeeding women, children, and people with liver or kidney disease should avoid berberine. Those on certain medications should also consult a doctor before use.

Can berberine interact with medications?

Yes, berberine can interact with medications like blood sugar-lowering drugs, blood pressure medications, and blood thinners. Always consult your healthcare provider before combining berberine with other medications.

What is the recommended dosage for berberine?

Typical dosages range from 500 to 1,500 mg per day, divided into two or three doses. It’s best to start with a lower dose and gradually increase it under medical supervision.


Photograph: nzooo/Envato
The information included in this article is for informational purposes only. The purpose of this webpage is to promote broad consumer understanding and knowledge of various health topics. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.