Scientists reveal how too much niacin could damage your heart

A recent study sheds light on the potential risks associated with elevated niacin levels in the body, particularly concerning heart health [1].

Niacin, also known as vitamin B3, has long been praised for its beneficial effects on various bodily functions. However, emerging evidence suggests excessive niacin intake could have detrimental consequences, particularly cardiovascular health.

The research published in Nature Medicine indicates a concerning correlation between high niacin levels and an increased risk of heart disease.

While niacin is essential for cellular metabolism and energy production, the study reveals that an excess of this vitamin may disrupt normal physiological processes, adversely affecting the cardiovascular system.

Niacin is commonly found in various foods and dietary supplements often contain high doses of this vitamin. However, the study warns against indiscriminate niacin supplementation, emphasizing the importance of moderation [2].

Consuming excessive amounts of niacin, whether through diet or supplements, could disrupt the delicate balance of biochemical pathways involved in heart function, thereby predisposing individuals to cardiovascular complications [3].

The mechanism behind the harmful effects of excess niacin on heart health involves its interaction with specific biological pathways. Notably, high niacin levels have been shown to interfere with lipid metabolism, leading to alterations in cholesterol levels and the accumulation of fatty deposits in the arteries [4].

These changes contribute to the development of atherosclerosis, a condition characterized by the narrowing and hardening of the arteries, which significantly increases the risk of heart disease and stroke.

Similarly, excessive niacin intake has been linked to other adverse cardiovascular effects, including inflammation and oxidative stress. These processes promote the progression of cardiovascular diseases by damaging blood vessels and impairing their function, ultimately compromising heart health.

The findings of this study underscore the importance of maintaining optimal niacin levels to safeguard cardiovascular wellbeing.

While niacin deficiency can have detrimental effects on health, mainly manifesting as pellagra, an overabundance of this vitamin may paradoxically increase the risk of heart disease. As a result, striking a balance in niacin intake is crucial for promoting overall health and preventing cardiovascular complications.

In light of these findings, individuals are advised to exercise caution when consuming niacin supplements and to consult healthcare professionals for guidance on appropriate dosage.

Additionally, a balanced diet that includes niacin-rich foods in moderation can help prevent both deficiency and excess of this vital nutrient, ultimately supporting optimal heart health.

While niacin offers various health benefits when consumed in moderation, excessive intake may harm heart health.

Understanding the potential risks associated with high niacin levels underscores the importance of mindful consumption and informed decision-making regarding dietary choices and supplement use to promote cardiovascular wellbeing.


The information included in this article is for informational purposes only. The purpose of this webpage is to promote broad consumer understanding and knowledge of various health topics. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.