Study: Coffee compound trigonelline increases NAD+ levels and slows muscle aging

A recent study published in Nature Metabolism has revealed an exciting finding for coffee lovers: a compound found in coffee called trigonelline might hold the key to slowing down muscle aging.

Researchers found that trigonelline, naturally present in coffee, can increase NAD+ levels in muscles. NAD+ plays a crucial role in various cellular processes, including energy metabolism and DNA repair, and its levels tend to decline as we age [1].

The study on mice showed that when trigonelline was administered to older mice, it led to higher levels of NAD+ in their muscles. This increase in NAD+ appeared to have a protective effect, slowing down the aging of muscle tissue and preserving muscle function.

So, what does this mean for humans? While more research is needed to confirm these findings and understand how they translate to human health, it’s an exciting step forward in the quest to combat age-related muscle decline.

The importance of this research extends beyond just muscle aging. Maintaining healthy muscle function is essential for overall health and quality of life, especially as we age [2].

We can prolong independence and vitality in older adults by uncovering potential strategies to preserve muscle health, such as trigonelline supplementation.

Of course, moderation is essential when it comes to coffee consumption. While trigonelline may offer some benefits, excessive caffeine intake can have adverse effects on health.

As with any dietary intervention, it’s best to consult a healthcare professional before making significant changes [3].

[1] https://www.nature.com/articles/s42255-024-00997-x
[2] https://newsinhealth.nih.gov/2020/03/maintain-your-muscle
[3] https://www.ncbi.nlm.nih.gov/books/NBK235263/

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