The 5 best NAD+ longevity supplements to buy in 2023

Here are the five best NAD+ supplements we recommend if you’re looking to live a longer, healthier life.

Supplements designed to boost nicotinamide adenine dinucleotide (NAD) levels have gained popularity in recent years. Research suggests NAD+ can help your body repair DNA, boost immunity and slow aging, but people also take it for short-term benefits such as increased energy. When choosing between the options available, much will depend on your current health condition and what you hope to get from your supplement.

What is NAD? 

NAD, or Nicotinamide Adenine Dinucleotide, is a critical molecule in all living cells. It plays a vital role in various biological processes, including energy metabolism, DNA repair and cellular signaling. NAD is a coenzyme which works with enzymes to facilitate these processes. 

Why does the body need NAD?

As we age, our NAD levels naturally decline, which can result in a number of health issues. Fortunately, researchers have discovered that supplementation with NAD precursors, such as nicotinamide riboside (NR), can boost NAD levels and potentially slow the aging process.

In addition to its role in biological processes, NAD has gained attention in the world of health and wellness due to its potential benefits in supporting brain health, reducing inflammation and improving metabolism. NAD also plays a critical role in the body’s defense against oxidative stress, which can cause cell injury and contribute to the development of chronic diseases [1]. 

How does NAD benefit you?

NAD supplementation has become increasingly popular in recent years, with some studies suggesting that it may help improve cognitive function, reduce the risk of age-related diseases and enhance exercise performance [2]. We still do not yet fully understand all the benefits of NAD supplementation – and any potential risks – but research is ongoing.

We’ve looked at what’s available on the market so that you can pick the one that’s right for you.

1. Wonderfeel® Youngr™

Wonderfeel® Youngr™ NMN provides a unique solution to aging; this NAD-boosting, patented formula has been developed by Harvard Med-trained entrepreneur and inventor Professor Andrew Salzman MD, who has worked in biomedical drug discovery for more than three decades.

With a dose backed by a recent human clinical trial based on cutting-edge science, Youngr aims to change the way you age. Taking it every day, you’ll notice improvements in skin elasticity and beneficial changes on the inside too – increased NAD levels will benefit your liver, brain and other organs, helping your body function better and extend its youthful resilience.

Youngr contains 900mg of NMN in just two capsules, and with an introductory offer of $73 for monthly subscribers, it’s a great value NMN product that will help keep your NAD+ levels at optimum.

2. Tru Niagen NAD+ supplements

This is one of the most popular supplements on the market. It contains nicotinamide riboside (NR) which is thought to be one of the fastest and most efficient NAD+ precursors available. It comes FDA approved with doses of 300mg of NR and makes all the usual claims associated with NAD+ of promoting cellular repair, accelerating metabolism and cellular energy production in order to improve your overall health and well-being. Taken over a period of time, therefore, it should have a positive impact on your health and may protect you against the onset of long-term disease.

What makes it so popular, if online reviews are anything to go by, is that it can have a more immediate effect by boosting your energy levels. Not only does it improve functions internally, hopefully boosting your chances of a longer life, but it is making you feel healthier and happier in the short term. In a world in which we prize immediate results, that is probably the reason why it sells so well.

3. Optima from Elevant

Last summer, Elevant released its latest supplement designed to boost NAD+ levels, Optima. It contains a high purity form of nicotinamide mononucleotide, NMN-C which, according to the company, “works within cells to support cognitive function, maintain daylong energy and focus, and promote balanced mood and quality sleep.” It comes in a handy chewable form which the company says has been optimized to keep you feeling fresh and energized all over.

Its high purity form caters for customers who are increasingly focusing on the purity of NMN content. The market is full of supplements, each of them making bold claims, not all of which have been tested. With a high purity precursor, Elevant hope to encourage customers who want their supplements to be as effective as possible.

The main selling point for this is cognition and brain health. NMN treatment, they say, has been shown to improve cognition and can potentially slow the progression of cognitive decline. They are, therefore, selling you both a long and short term offering – take this supplement, they say, and not only will you feel better and sharper today, but you will also reduce your chances of developing forms of dementia in later life.

Last summer, Elevant released its latest supplement designed to boost NAD+ levels, Optima. It contains a high purity form of nicotinamide mononucleotide, NMN-C which, according to the company
Photograph: Mariana Rascao/Unsplash

4. Elevant Prime NAD+ supplements

The immediate precursor to Optima was Prime from Elevant. Once again, it boasted a high purity form of nicotinamide mononucleotide (NMN-C) which promises to improve cognition and help you feel better and more alert while slowing the onset of long-term cognitive decline.

“For thousands of years, the human body has been creating NMN to fuel cells and keep us healthy,” said Elevant’s chief scientist Dr Alessia Grozio. “With Elevant Prime, we have taken the best of nature’s design and modern science to help people unlock a multitude of potential health benefits as a result of boosting NAD+.”

In a world in which purity and provenance can be hard to define in the supplement market, Elevant say they are bringing a sense of clinical evaluation to the sector by delivering clinically tested methods to ensure a safe and effective supplement.

5. Alive by Science NMN Sublingual tablets

Previously known as Alive by Nature, this comes in two forms – either sublingual tablet which are placed under the tongue or in NMN powders. This, they say, is the world’s first sublingual tablet for NMN, although other sublingual powders are available. This supplement claims to be backed by a triple lab tested promise for quality assurance. For transparency they also provide COA certificates as well as monk fruit extract to give it a nicer taste.

Photograph: Ready Made/Pexels
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