ALA (alpha lipoic acid) is a coenzyme that helps with metabolism.
As a water- and fat-soluble antioxidant, it can work in a variety of tissues and physiological systems. Additionally, ALA assists in recycling other antioxidants, such as vitamins C and E, by restoring their antioxidant properties.
Researchers have investigated whether ALA can decrease inflammation, prevent oxidative stress, and improve insulin sensitivity in type 2 diabetics. Despite the lack of research, it’s widely used as a supplement.
There have been a lot of studies showing the benefits of (ALA) on health. Some of these are:
Alpha lipoic acid as antioxidant
Free radicals are unstable chemicals that can harm cells and aid in the onset of chronic illnesses. Alpha lipoic acid is a potent antioxidant that can neutralize free radicals. Water- and fat-soluble, ALA can work in a variety of tissues and bodily system [1].
There have been a variety of applications of ALA’s antioxidant action. These include the management of diabetes, cardiovascular disease and neurological disorders.
People with type 2 diabetes can benefit from ALA by increasing insulin sensitivity and decreasing oxidative stress. This can aid in blood sugar regulation and protect against complications. ALA may prevent cardiovascular disease by reducing oxidative stress and inflammation in the blood vessels.
Although ALA is usually safe, it can cause upset stomachs and rashes. Before taking any supplements, it’s vital to consult a healthcare professional because ALA can interact with several drugs.
Improved insulin sensitivity
It has been demonstrated that type 2 diabetics’ insulin sensitivity and glucose uptake can be improved by alpha lipoic acid. People with type 2 diabetes frequently exhibit resistance to the effects of the hormone insulin. This results in high blood sugar levels. Insulin is a hormone that helps to control blood sugar levels [2].
According to research, ALA can increase insulin sensitivity by increasing the absorption of glucose by cells, lowering insulin resistance and inflammation, and guarding against oxidative stress. The ability of blood arteries to widen and increase blood flow, which is improved by endothelial function, may also be improved by ALA.
Additionally, several studies have demonstrated that taking ALA supplements helps lessen the signs of diabetic neuropathy, which is nerve damage that can develop as a result of diabetes, and can help regulate blood sugar levels. Furthermore, ALA may assist persons with diabetes lower their risk of cardiovascular disease, according to certain research.
Reduced Inflammation
Due to the anti-inflammatory characteristics of alpha lipoic acid, inflammation may be lessened throughout the body. A typical immunological reaction, inflammation aids in the body’s defense against injury and infection. However, a number of chronic disorders, including diabetes, cardiovascular disease, and Alzheimer’s disease, might be facilitated by chronic inflammation.
According to research, ALA may aid to decrease inflammation by lowering the generation of pro-inflammatory cytokines and altering the activity of many inflammatory pathways. Additionally, ALA may offer defense against oxidative stress, another factor that can fuel inflammation [3].
People with a variety of medical disorders, such as diabetes, metabolic syndrome, and rheumatoid arthritis, might benefit from taking ALA supplements to help lower inflammatory indicators like C-reactive protein (CRP) and interleukin-6 (IL-6).
Nerve health benefits
Researchers have looked at the effects of alpha lipoic acid in preserving the health of the nerves and reducing the symptoms of neuropathy, a typical consequence of diabetes. The condition known as neuropathy can result in pain, numbness, and tingling in the hands and feet [4].
By lowering oxidative stress and inflammation, two factors that can lead to nerve injury, ALA may aid in protecting against it. Additionally, ALA may aid in enhancing nerve conduction velocity – the rate at which nerve signals move and blood flow to the nerves.
ALA supplements help lessen discomfort and enhance sensory function in diabetics with neuropathy, among other problems. Additionally, some studies have shown that ALA could also help persons who suffer other kinds of neuropathy, such those brought on by chemotherapy or HIV.
Skin health benefits
The potential advantages of alpha lipoic acid for the health of the skin have been investigated. As an antioxidant, ALA can aid in scavenging free radicals and guarding against oxidative stress, both of which can hasten the appearance of wrinkles, fine lines and other aging symptoms.
ALA may aid in preventing sun damage, a significant contributor to skin aging. Inflammation and oxidative stress brought on by UV radiation may be lessened and skin cell damage may be repaired with the aid of ALA [5].
According to some studies, ALA may lessen the appearance of fine lines and wrinkles by encouraging the creation of collagen, a protein that provides the skin its firmness and suppleness. Additionally, ALA may aid to enhance skin tone and texture as well as lessen the appearance of hyperpigmentation.
Cardiovascular health benefits
Oxidative stress, which can lead to the onset of cardiovascular disease, can be protected against by ALA. Furthermore, it could aid in lowering inflammation, another risk factor for heart disease [6].
By lowering LDL (“bad”) cholesterol levels and raising HDL (“good”) cholesterol levels, ALA may aid in the improvement of lipid profiles. The ability of blood arteries to widen and increase blood flow, which is improved by endothelial function, may also be improved by ALA. It may assist in lowering blood pressure and preventing the onset of atherosclerosis, which is the accumulation of plaque in the arteries, by enhancing endothelial function.
Taking ALA supplements can help those with a variety of medical illnesses, such as type 2 diabetes, metabolic syndrome, and heart failure, improve their cardiovascular health metrics.
Weight loss
ALA has been researched for its ability to improve insulin sensitivity and reduce inflammation, but there is little proof that it can be used to help people lose weight. In overweight or obese people, ALA may help reduce body weight and body fat, presumably through enhancing insulin sensitivity and elevating energy expenditure. To properly comprehend how ALA affects weight reduction, additional study is necessary because the findings of these trials are contradictory [7].
A successful weight loss strategy must include a balanced diet, frequent exercise and lifestyle adjustments. It’s vital to see a healthcare professional before taking any supplements since ALA supplements can interact with some drugs and large doses of ALA can have adverse effects.
Guidelines For Usage
To use alpha lipoic acid, you can follow these suggestions:
- Before using ALA supplements, especially if you have a medical condition or are on any drugs, speak with a healthcare professional.
- Observe the dosing instructions on the supplement’s package. Side effects from high doses of ALA might include skin rash and disturbed stomach.
- To enhance absorption and lower the chance of gastrointestinal disturbance, take ALA with meals.
- For a more powerful impact, think about taking ALA together with additional antioxidants like vitamins C and E.
- Be cautious that ALA may interfere with pharmaceuticals used to treat diabetes, thyroid hormone replacement treatment and chemotherapy. If you are currently using any of these drugs, consult a doctor before taking it.
- There are other topical ALA formulations that may be a better choice for those who are worried about possible adverse effects.
- ALA is not a replacement for a balanced diet and active lifestyle. For general health and wellbeing, it’s crucial to eat a balanced diet full of fruits, vegetables and whole grains and to exercise frequently.
Though ALA has demonstrated potential health advantages in studies, further study is still required to completely comprehend its effects.
Side effects
When used at prescribed quantities, alpha lipoic acid is generally regarded as safe. However, certain people may have negative consequences from high dosages, such as:
- Stomach upset: For some people, ALA might result in nausea, vomiting, and discomfort in the stomach.
- Skin rash: Those who use ALA supplements occasionally have skin rashes.
- Hypoglycemia: ALA may drop blood sugar levels, which is risky for those with hypoglycemia or diabetes.
- Medication interactions: ALA may interact with a number of pharmaceuticals, including those used to treat diabetes, thyroid hormone replacement treatment, and chemotherapy.
- Allegies: An allergic response to ALA supplements may occur in some persons, which may result in symptoms including wheezing, hives, and swelling of the face, lips, tongue or neck.
Before taking any supplements, it’s crucial to see a healthcare professional, especially if you have a medical condition or are already on medication. Stop using ALA supplements and speak with your doctor if you develop any negative side effects.
[1] https://pubmed.ncbi.nlm.nih.gov/16849425/
[2] https://pubmed.ncbi.nlm.nih.gov/17178700/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989440/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836194/
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927099/
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407629/
[7] https://pubmed.ncbi.nlm.nih.gov/8958163/
