The pros and cons of nicotinamide riboside supplements

A notable development in the quest for vitality and longevity is the availability of nicotinamide riboside (NR) supplements. The coenzyme NAD+’s precursor, NR, catalyzes cellular energy synthesis. 

Numerous advantages are provided by NR supplements by raising NAD+ levels. They boost your metabolism, improve cognitive function and offer the tantalizing potential for slowing down the aging process. 

NR supplements have become prominent in a society where we yearn for perfect health and a full living. 

Join us as we set out on a quest to discover the amazing benefits of NR, which will enable you to take charge of your health in a way that has never been possible. 

What is nicotinamide riboside (NR)?

A naturally occurring substance called nicotinamide riboside (NR) can be found in trace levels in several foods, including milk. It is a member of the vitamin B3 family, often known as niacin. 

Nicotinamide adenine dinucleotide (NAD+), a key coenzyme that is involved in a number of cellular functions, is a precursor to NR. Our bodies transform NR or NR supplements into NAD+ when we take them. 

When our cells manufacture energy through cellular respiration, NAD+ is involved in the transport of electrons. 

NR supplements raise NAD+ levels, which improves our cells’ capacity to produce energy and supports general metabolism.

The potential anti-aging properties of NR have drawn attention. NAD+ levels normally drop with aging, which affects cellular activity and energy generation. 

It is thought that by regenerating NAD+ with NR supplementation, we may be able to lessen some of the effects of aging and enhance cellular health [1].

Additionally, NR has demonstrated the potential in promoting mental wellness and cognitive function. 

NAD+ is essential for preserving neuronal health and fostering the best possible brain function. 

NR supplements may promote mental clarity and cognitive performance by raising NAD+ levels.

What are the pros of taking nicotinamide riboside supplementation?

Supplements containing nicotinamide riboside (NR) have drawn interest due to their potential to improve general health and well-being. 

NR offers a number of possible advantages by serving as a precursor to nicotinamide adenine dinucleotide (NAD+). 

Let’s go more into the benefits of NR supplementation:

Boosts NAD+ levels

The coenzyme nicotinamide adenine dinucleotide (NAD+), which is necessary for a number of cellular processes, is formed from nicotinamide riboside (NR). 

NR supplementation helps vital cellular functions including the production of energy, DNA repair and gene expression by raising NAD+ levels. 

This may result in enhanced cellular health and performance as a whole.

Boosting NAD+ levels

Enhances energy metabolism

Particularly in the mitochondria, the powerhouse of our cells, NAD+ is essential for energy metabolism. 

NAD+ levels are elevated by NR supplements, which optimize cellular energy production and may increase vitality, enhanced physical performance and decreased fatigue [2].

Has potential anti-aging effects

Age-related health issues and cellular dysfunction are caused by a normal decline in NAD+ levels. By restoring NAD+ levels, NR supplementation can stop this reduction. 

According to studies, increasing the availability of NAD+ with NR supplementation may support healthy aging, enhance cellular function and possibly slow down the effects of aging.

Supports cognitive function and brain health

Keeping the brain functioning at its best requires an adequate supply of NAD+. 

NAD+ availability in the brain has been demonstrated to be improved by NR supplementation, which may improve cognition, memory, attention and general brain health [3]. 

NR may improve cognitive well-being and mental sharpness by promoting neuronal health and signaling.

Has cardiovascular health benefits

The regulation of blood vessel function, enhancement of blood flow and support of heart health are just a few ways that NAD+ is engaged in cardiovascular health. 

By encouraging healthy blood vessel function, preserving optimal blood pressure levels and lowering oxidative stress, NR supplementation has shown promise in boosting these characteristics. 

These advantages could lead to better cardiovascular health.

Improves exercise performance and endurance

Supplements with NR have been associated with increased exercise performance and endurance. 

NR may boost physical performance, increase stamina and facilitate recovery from intense physical activity by improving cellular energy generation and metabolism. 

Athletes and those who regularly participate in physical activity may find this to be particularly advantageous.

Supports metabolic health

NAD+ has a complex role in metabolic processes such as insulin sensitivity and glucose metabolism. 

NR supplementation has demonstrated promise in supporting metabolic health by assisting in regulating blood sugar levels, enhancing insulin function, and encouraging appropriate weight control. 

An improved metabolism that is more balanced and effective may result from these effects.

Has potential neuroprotective effects

The survival and well-being of neurons have been supported by NAD+, which has been linked to neuroprotection. 

NR supplementation may have neuroprotective properties that lessen the impacts of age-related cognitive decline and neurodegenerative diseases. 

Wide-ranging applications

Since NR can boost NAD+ levels and improve cellular function, it has been investigated in a number of health and wellness-related fields. 

Its promise in areas including lifespan, mitochondrial health, DNA repair, immunological function and metabolic diseases is currently being researched. 

Due to its adaptability and possible uses, NR is a fascinating topic of continuing scientific research.

What are the cons of nicotinamide riboside (NR) supplementation?

While the possible benefits of nicotinamide riboside (NR) supplements have attracted attention, it is important to consider the limitations and potential risks as well. 

The following are some cons of NR supplementation:

Limited long-term safety data

Due to the fact that NR supplements are a recent addition to the market, there are few long-term safety data available. 

While NR is often regarded as safe for short-term usage, its effects on the body when supplemented over an extended period are still not fully known. 

It is crucial to use caution and pay attention to new studies being conducted in this field.

Potential side effects and interactions

While NR is widely embraced, some people may develop side effects such as gastrointestinal discomfort, nausea or headaches. These side effects are usually minor and short-lasting. 

However, it is essential to be aware of any potential negative effects and discontinue use if they happen. 

Additionally, there may be interactions between NR supplements and some medications or health issues. 

Before beginning NR supplementation, speaking with a medical practitioner is crucial, especially if you have underlying health issues or are using medication.

Cost considerations

Compared to other dietary supplements, NR supplements might be a bit costly. Depending on the brand, dosage and amount, NR prices might change. 

The costs of including NR in a health routine should be carefully assessed when considering long-term usage. 

If cost is a major problem, it is crucial to balance the possible advantages against the cost and look into other possibilities.

Lack of regulation and quality control

NR supplements are not subject to the same level of regulation as the rest of the dietary supplement industry. 

Variations in product quality and potency may be caused by the absence of standard regulations and quality control procedures. 

When buying NR supplements, it’s critical to stick with reputable suppliers that follow appropriate production processes and to search for third-party testing and quality certifications [4].

Lack of regulation and quality control
Photograph: YuriArcursPeopleimages/Envato

Efficacy compared to other NAD+ precursors

Although NR has received a lot of attention, alternative NAD+ precursors, such as nicotinamide mononucleotide (NMN), are also being investigated for potential benefits. 

Research is being done to determine NR’s efficacy and comparative benefits over alternative NAD+ precursors. 

It is crucial to consider the constantly developing body of research in this area and speak with medical professionals who are up to date on the most recent discoveries.

Individual variability in response

Supplemental NR may cause varied reactions in some individuals. The results and potential benefits received might be influenced by factors including age, general health, genetics and way of life. 

While some people might see a difference, others might only detect a small difference or no change at all. 

It’s critical to control your expectations and acknowledge that everyone will have different results.

Incomplete understanding of mechanisms

The specific mechanisms by which NR exerts its beneficial effects are still not entirely known, despite the fact that its effects on NAD+ levels and cellular functions are well-documented. 

The complex mechanisms behind NR supplementation are still under investigation and being fully understood by the scientific community. 

Additional investigation is required to clarify these pathways and offer a more thorough knowledge of NR’s effects on the body.


Supplements containing nicotinamide riboside (NR) have enormous potential to enhance health and energy. 

NR has the potential to improve cardiovascular health, maintain cognitive function, increase the production of energy and promote healthy aging by raising NAD+ levels. 

The advantages may outweigh the disadvantages despite factors including the lack of long-term safety evidence and expense. 

NR gives a compelling chance to unleash your body’s ultimate potential and live a life of limitless energy and well-being as the scientific community continues to look into its possibilities. 

Take full advantage of the benefits of NR supplementation and set out on a path to a healthier, more energetic you.


Are there any dangers taking NAD supplements?

For the majority of people, taking NAD supplements like nicotinamide riboside (NR) is widely regarded as safe. However, there may be dangers and side effects, such as headaches or gastrointestinal discomfort, which are only temporary, with any supplement.

Is it safe to take nicotinamide?

Nicotinamide is generally considered safe for most individuals when taken at recommended doses. It is a form of vitamin B3 and is commonly used as a dietary supplement.

Does nicotinamide have side effects on the liver?

Nicotinamide is generally well-tolerated and does not commonly cause liver side effects when taken at recommended doses. It is considered safe for most individuals, including those with liver conditions.


Photograph: olenasvechkova/Envato
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