Best NMN supplements for longevity to buy in 2023

The NMN supplements market is booming, but how do you know which are the best options for you?

What are NMN supplements?

The search for the elixir of life has obsessed mankind for centuries. Today, much of that search has focused on supplements – a growing range of products that claim to make you feel healthier, more alert and keep you younger for longer.

The key element in many of these is nicotinamide mononucleotide (NMN). The body uses this molecule to generate NAD+ which is key to biological functions such as cellular energy, metabolic health and the immune system. These functions decline as we age, leading to the onset of all sorts of problems including heart disease, cancer and neurological disorders.

Different types of NMN supplements

NMN supplements are gaining traction; according to data from Precision Reports, the global NMN market is expected to grow to $386 million by 2027. New products are appearing on the market by the day, and choosing between them can feel rather tricky, so here are a few products which may help you achieve your healthspan goals.


The expert research behind Purovitalis™ means its products are designed to counteract the effects of aging, supporting your journey towards a healthier, more fulfilling life as you age. The Purovitalis team keeps up to date with the latest research, and a clinical study is also underway to ensure their products’ effectiveness; as the only brand producing NMN in Europe, the company sources its ingredients exclusively from the continent, guaranteeing quality and purity.

The company’s innovative product lineup offers three variations to cater to your needs: Pure NMN Powder, its most popular Liposomal NMN Capsules and the Liposomal NMN + Resveratrol Bundle. Each product is designed to enhance your body’s natural ability to repair and regenerate cells while maintaining optimal energy levels. 

However, it’s not just the ingredients that matter, it’s the delivery system, and getting the NMN to where it is needed and ensuring it isn’t broken down by the gut. What really caught our eye is Purovitalis’ patented Liposomal Technology, which, they say, boosts NMN bioavailability by a whopping 90%. While regular NMN may have great impact on NAD+ levels, liposomal NMN can work faster, more effectively and with extended release for a longer lasting effect. Because this delivery tech significantly increases the effectiveness at much smaller serving sizes, you get much more NMN bang for your buck. 

Sourced exclusively from Europe, Purovitalis’ Pure NMN Powder provides both purity and safety; the company’s Liposomal NMN Capsules offer convenience and efficiency, perfect for those on the go, containing 60 third-party tested, 99% pure Nicotinamide Mononucleotide capsules. Or, if it’s a supplement packed with rejuvenating power that you are after, why not check out Purovitalis’ Liposomall NMN + Resveratrol bundle? Combining NMN’s youth-preserving properties with resveratrol’s cell-protecting benefits, it is designed to unlock your body’s longevity potential.

Shop Purovitals NAD Booster Collection

Shop for Purovitalis NMN Capsules Liposomal

Shop for Purovitalis NMN Powder Pure

Elysium Signal

Research has shown that NAD+ is central to hundreds of metabolic processes, but this is especially true in the mitochondria, where NAD+ plays a crucial role in the key reactions that take place.

The mitochondria are the powerhouses of the cell, taking glucose and oxygen and converting it into the cellular energy we need to grow, repair and function. However, as we age, mitochondrial function declines, and this means less energy for repair and renewal.

Signal targets metabolic aging by supplying declining metabolites and acting to preserve and help generate new mitochondria.

The renowned aging researcher Leonard Guarente, PhD, is Elysium’s founder and chief scientist; he describes Signal as a novel, mitochondria-centric product that is “formulated to counter aging-dependent declines in metabolism by promoting youthful energetics and metabolic efficiency”.

Aging is a double whammy for our mitochondria; not only do NAD+ levels drop off as we age, but the activity of NAD-dependent enzymes like SIRT3 declines as a result of aging-induced changes in cellular metabolism. SIRT3 helps facilitate key reactions inside the mitochondria, as well as protecting and generating new mitochondria, so this decline is bad news.

Signal’s SIRT3 Metabolic Activation Complex, honokiol and viniferin, are designed to work synergistically with NMN to activate SIRT3 to promote mitochondrial health and synthesis, which in turn support metabolic health.

As well as increasing NAD+ levels by 40% and activating SIRT3, Signal also promotes healthy metabolic aging by maintaining insulin sensitivity (helping to keep blood sugar at a healthy level), supporting vascular heath (critical for athletic endurance) and supporting the process of brown fat thermogenesis – converting sugar and fat into heat to maintain body temperature and help support a healthy metabolism.

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Elevant NMN-C®

Elevant NMN-C® aims to bring scientific rigour to the supplements market. Elevant, in partnership with the Buck Institute and Seneque Lab, has developed a proprietary form of NMN, called NMN-C®. Using fully synthetic processes, the result is an NMN that is “most likely to be purer and more efficient at raising NAD+ levels” than other NMN products, says Dr Eric Verdin, President of the Buck Institute.

Endorsed by Dr Frank Lipman, a leader in the functional medicine field, Elevant has conducted what it claims to be the first study of its kind to be undertaken on NMN : an OECD toxicology study. The study showed NMN-C® to be an ‘extremely well-tolerated option’ even at highest concentration level (>1500mg/kg/day). NMN-C is used in in-human trials, meaning it meets clinical levels of safety, purity and quality. With 11 clinical trials underway, NMN-C is the most extensive in-human NMN research program to date, and it is the only pharma grade NMN available in the market.

Based on this research, Elevant has developed two products: Prime capsules and Optima chewable tablets. Designed to work together as a daily combination, these complementary delivery forms target different routes of absorption, one aiming for the long-term while the other releases immediate effects:

  • Elevant Prime  Capsules: zero in on cellular repair to decrease risks of metabolic diseases, such as diabetes, or cardiovascular dysfunctions, providing your cells with the fuel they need to operate and combat infections.
  • Elevant Optima Chewable tablets: aid in combatting plunges in energy and focus. Optima enters your body through sub-lingual sensors, allowing NMN-C® to operate faster and promotes brain clarity and enhanced cognition functions.

In an environment in which many suppliers make bold and over-inflated claims about the efficacy of their supplements, Elevant focuses on scientific rigour and analysis and aims to appeal to those who want to see independent recognition of a company’s claims before committing to a purchase.

Shop for Elevant Optima

Shop for Elevant Prime

LIPO NAD+ Complete – Powdered Liposomal NAD+, NMN, & NR

For one of the strongest and fastest acting supplements on the market, look to Liposomal NMN from Renue by Science. This is a powder-based liposomal NMN product which has been shown to be up to six times more bioavailable than liquids. It takes advantage of liposomes – delivery vehicles that transport substances into the body either by facilitating absorption directly in the mouth or by preventing its breakdown by stomach acid. The product comes in 250mg tables and has been FDA inspected and ISO-Certified.

The Liposomal NAD+ Complete Oral Spray is a new product in their line. Ingredients are delivered orally to be absorbed through mucous membranes and absorbed directly into the bloodstream.

As with IV injections, sublingual delivery provides peak serum NMN, NAD+ and NR elevations. In addition to allowing active ingredients to reach alternative tissues, liposomes prolong circulation time in the blood.

Shop for Liposomal NAD+

Shop for Lipo NAD⁺ Complete Oral Spray with NAD⁺, NMN and NR

Making your choice

These are just some of the NMN products available, with a quick search of the market revealing myriad options. The best way to check on quality is to look at the ingredients and ascertain which products have been independently tested and approved. If you find a product which is significantly cheaper than the others, you should consider that there may be a very good reason for that – if it seems too good to be true, it probably is.

Photograph: prathanchorruangsak/Envato
The information included in this article is for informational purposes only. The purpose of this webpage is to promote broad consumer understanding and knowledge of various health topics. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.