What supplements are good for the gut-brain axis?

The gut-brain axis, a complex communication network, plays a crucial role in maintaining our overall health.

It’s where our digestive system and mental wellness meet, influencing everything from our mood to our immune response.

This blog dives into how the right supplements can support this vital link. Whether you’re a wellness enthusiast or just starting to focus on your gut health, this guide aims to provide valuable insights.

It’s about understanding the power of supplements in maintaining a harmonious gut-brain relationship and how you can use them to enhance your overall well-being.

What supplements are good for gut health?

Navigating the world of supplements for gut-brain health can feel overwhelming. Let’s simplify it and focus on what really matters.

Let’s discuss the types of supplements that are beneficial for the gut-brain axis and why they’re important.

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Probiotics, often hailed as the superheroes of gut health, are live microorganisms that provide a health benefit when consumed in adequate amounts [1]. This balance is crucial not just for digestion but also for overall wellbeing.

  • They help keep harmful bacteria in check, ensuring your digestive system runs smoothly.
  • There’s a fascinating link between your gut and brain. Probiotics can positively impact mental health, often improving mood and cognitive function.
  • A healthy gut means a strong immune system, and probiotics play a key role in this.

Key strains to look for include Lactobacillus and Bifidobacterium. These have been studied extensively for their benefits in both gut and brain health.

A happy gut often means a happy mind, and probiotics are a simple yet effective way to support this connection.


Prebiotics are the unsung heroes of gut health, playing a pivotal role in nurturing your gut’s microbiome.

Unlike probiotics, prebiotics aren’t bacteria themselves; they’re the food that your beneficial gut bacteria feast on. Think of them as the fuel that keeps your gut flora thriving.

  • They’re a type of dietary fiber found in various fruits, vegetables, and whole grains.
  • By feeding the good bacteria in your gut, prebiotics help improve digestion and enhance the absorption of important nutrients.
  • There’s evidence suggesting prebiotics can have a positive impact on your mood, thanks to their role in gut-brain communication.

However, for those looking for a more concentrated dose, prebiotic supplements are an excellent option.

Incorporating prebiotics into your diet is a straightforward way to support a healthy gut ecosystem, which in turn, can significantly influence your overall health and wellbeing.


Omega-3 fatty acids

Omega-3 fatty acids are essential fats that your body can’t make on its own, so it’s vital to get them from your diet. They’re key players in maintaining brain health and a well-functioning gut.

  • These fats are essential for cognitive function. Consuming them helps in enhancing memory function and boosting mood levels.
  • Omega-3s help reduce inflammation in the gut, which is essential for a healthy digestive system.
  • They’re also known for their heart-healthy benefits, like reducing blood pressure and improving cholesterol levels.

You can find Omega-3s in fatty fish like salmon, mackerel, and sardines. If fish isn’t your thing, flaxseeds, chia seeds, and walnuts are good plant-based sources.

For those who struggle to include enough Omega-3s in their diet, supplements like fish oil capsules are a convenient alternative.

Including Omega-3s in your diet is a smart move for both your gut and brain health, offering a range of benefits that extend across your entire body.

Vitamin D

Known as the “sunshine vitamin,” vitamin D is a powerful substance that does more for your health than merely support strong bones. It has a big impact on the gut-brain axis, which affects mental and digestive health.

  • It contributes to the preservation of the intestinal lining, which is necessary to stop diseases like leaky gut syndrome. Better nutrient absorption and a decreased risk of digestive diseases are associated with a healthy gut lining.
  • Numerous mental health problems are associated with low vitamin D levels. This vitamin can help fight anxiety and sadness and is essential for mood regulation [2].
  • A healthy immune system, which aids in the body’s defense against infections and illnesses, depends on vitamin D.

Although sunlight is considered the most efficient natural source of Vitamin D, supplements are a great alternative, especially in colder months or for those with limited sun exposure.

Including enough Vitamin D in your diet or through supplements is a smart strategy for ensuring your gut and brain stay healthy and connected.

B vitamins

B vitamins are a group of nutrients that play a crucial role in overall health, particularly in supporting the gut-brain axis. These vitamins are essential for maintaining both mental and digestive health.

  • They are vital in creating neurotransmitters, which are chemicals that help the brain communicate with the rest of the body. This is key for good mood and cognitive function.
  • The B vitamins keep you alert and active by assisting in the conversion of food into energy.
  • They help to keep the nerves lining the digestive tract healthy, which promotes easy digestion.

Particularly important are Vitamin B12 and B6. B12 is crucial for brain health and is often found in animal products, making supplementation necessary for vegetarians and vegans.

B6, on the other hand, is essential for mood regulation and is found in various foods, including poultry, fish, and some vegetables and fruits.

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It is a vital mineral with a key role in numerous bodily functions and is also known as the ‘relaxation mineral’.

This mineral is particularly important for the gut-brain axis, influencing both digestive and mental health.

  • It facilitates improved digestion and guards against problems like constipation by assisting in the relaxation of the muscles in your digestive tract.
  • Magnesium is well known for its capacity to lower anxiety and stress, both of which can improve gut health.
  • By regulating neurotransmitters, it aids in improving sleep quality, which is essential for both brain and gut health.

Found in foods like leafy greens, nuts, seeds, and whole grains, magnesium is also available as a supplement. It’s particularly beneficial for those dealing with stress, muscle cramps, or sleep issues.


Zinc is a trace mineral, but its impact on your body is anything but minor. It’s a crucial player in maintaining both gut and brain health, making it an essential part of your diet.

  • Zinc helps maintain the strength and integrity of the intestinal lining, reducing the risk of leaky gut syndrome. This is key for preventing unwanted substances from entering the bloodstream.
  • This mineral plays a significant role in neural development and function. Adequate zinc levels are linked to improved mood and cognitive function, possibly reducing symptoms of depression and anxiety.
  • Zinc boosts immune function, which is vital for overall health and well-being.

You can find zinc in foods like meat, shellfish, legumes, and nuts. For those who may have dietary restrictions or need an extra boost, zinc supplements are an effective option [3].

It’s important, however, to stick to recommended doses, as too much zinc can interfere with the absorption of other minerals and cause nausea.

How can I improve my gut-brain axis?

Supporting the gut-brain axis isn’t just about what you ingest; it’s also influenced by your lifestyle choices. Here’s how you can make mindful decisions to foster a healthier connection between your gut and brain:

Balanced diet

Your gut health is heavily influenced by your diet. Aim for a balanced intake of fiber-rich fruits and vegetables, lean proteins, and healthy fats [4].

Avoid excessive processed foods, sugar, and artificial additives. A diverse diet ensures a wide array of nutrients for both your gut and brain.

Stay hydrated

Drinking enough water is crucial for digestion and overall health. It helps transport nutrients to your cells and aids in waste elimination.

Dehydration can lead to constipation and other gut issues, affecting your mood and cognitive function.

stay hydrated

Mindful eating

Slow down and savor your meals. Eating mindfully can improve digestion and prevent overeating. It also promotes a relaxed state, which is beneficial for your gut and mental well-being.

Regular physical activity

Exercise supports a healthy gut by promoting motility and blood flow. It’s also known to boost mood and cognitive function. Aim for at least 150 minutes of moderate-intensity aerobic activity per week.

Manage stress

Chronic stress can wreak havoc on your gut-brain axis. Look for stress-reduction methods that suit you, such as deep breathing, yoga, meditation, or relaxing hobbies. A calm mind contributes to a healthy gut.

By incorporating these lifestyle considerations into your daily routine, you can provide robust support for your gut-brain axis.

Remember that small, sustainable changes can lead to significant improvements in your overall health and well-being.

Closing thoughts

Taking care of your gut-brain axis is a proactive step towards better overall health and well-being.

The supplements we’ve discussed, including probiotics, prebiotics, Omega-3 fatty acids, Vitamin D, B Vitamins, magnesium, and zinc, all play unique roles in supporting the intricate connection between your gut and brain.

Remember, your gut and brain are in constant communication, and the choices you make can influence this connection positively.

By taking these actions, you can empower yourself to maintain a healthier gut-brain axis and enjoy the many benefits it brings to your life.

Your journey towards well-being starts with these steps, so take them with confidence and commitment. Your gut and brain will thank you for it.


What vitamins are good for the gut-brain axis?

Vitamins that are particularly beneficial for the gut-brain axis include Vitamin D, B Vitamins (especially B6 and B12), and Zinc. These vitamins play crucial roles in maintaining gut health, supporting neurotransmitter function, and promoting overall well-being.

How can I improve my gut-brain axis?

You can improve it by maintaining a balanced diet, managing stress, staying physically active, and considering supplements like probiotics and Omega-3 fatty acids.

How do I reset my gut brain connection?

To reset your gut-brain connection, focus on a gut-friendly diet, stress reduction, quality sleep, and regular exercise. These actions can help improve the connection between your gut and brain.

How do you heal your gut-brain axis?

To heal your gut-brain axis, prioritize a balanced diet with fiber, probiotics, and Omega-3s, while also managing stress, getting enough sleep, and staying active.

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[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045285/
[2] https://www.healthline.com/nutrition/depression-and-vitamin-d
[3] https://www.healthline.com/nutrition/best-foods-high-in-zinc
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455721/

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