Why should you care about your inflammation score?

Longevity.Technology System users:

To check your inflammation score:

  1. Download the LT System app on your Android or Apple smartphone.
  2. Open the LT System app and select ‘Epigenetics.’
  3. Scroll down and find ‘Inflammation Score’
  4. Now, scroll down to find your results and recommendations.

Not a user yet?

That’s OK, you can sign-up for your Epigenetic DNA test here.


Inflammation is a double-edged sword in our body. While it is critical in our immune response, chronic inflammation can lead to numerous health issues.

To understand and manage this balance, the concept of the inflammation score has gained prominence. This score is pivotal in predicting various health outcomes and can be assessed through different metrics.

What does an inflammation score mean?

An inflammation score is a quantitative measure used to assess the body’s inflammation level. It combines various biomarkers, clinical parameters, and other specific indicators to provide a comprehensive evaluation of inflammatory activity. 

For instance, the Malnutrition-Inflammation Score (MIS) ranges from 0 to 30 and evaluates protein-energy wasting by considering changes in dry weight, dietary intake, and muscle wasting [1].

Similarly, the Low-Grade Inflammation (LGI) Score combines parameters like C-reactive protein levels, leukocyte counts, and the neutrophil-to-lymphocyte ratio to forecast recovery prospects following an acute ischemic stroke [2].

Moreover, the Systemic Inflammation Score (SIS) has emerged as a significant predictor of contrast-associated Acute Kidney Injury (CA-AKI) and long-term mortality risk [3].

These inflammation scores are essential tools for evaluating inflammation levels and anticipating health outcomes across various medical conditions. By understanding these metrics, you can effectively and proactively manage your health. 

The inflammation score helps diagnose, monitor, and manage inflammatory conditions, offering valuable insights into a person’s health status and potential risks for chronic diseases.

How do you get your inflammation score?

Understanding your inflammation score is crucial for maintaining overall health and preventing chronic diseases. The inflammation score is a valuable tool that helps quantify inflammation in the body, providing insights into your health status [4].

There are three primary methods to measure inflammation: traditional inflammation tests, advanced inflammation scores, and the epigenetics DNA test

1. Traditional inflammation tests

Traditional methods to assess inflammation include blood tests such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) [5], [6]. These tests measure the levels of certain proteins and the rate at which red blood cells settle at the bottom of a test tube, both of which increase with inflammation.

CRPESR
Measures acute inflammation and infectionIndicates inflammation by measuring the sedimentation rate of red blood cells
Responds quickly to inflammation (within hours)Responds more slowly to inflammation (over days)
Rapid response to inflammation, specific to acute inflammatory conditionsUseful for detecting chronic inflammation and monitoring autoimmune diseases
Can be influenced by factors other than inflammation (e.g., obesity, smoking)Less specific than CRP; influenced by various non-inflammatory factors

2. Advanced inflammation scores

Besides traditional tests, advanced inflammation scores provide a more comprehensive picture of inflammation. These scores combine multiple parameters to predict health outcomes more accurately.

  • Malnutrition-Inflammation Score (MIS)

From 0 to 30, the MIS assesses protein-energy wasting by evaluating changes in dry weight, dietary intake, and muscle wasting. It’s a valuable indicator for predicting overall health and nutritional status [7].

  • Low-Grade Inflammation (LGI) Score

The LGI Score integrates factors like CRP levels, leukocyte counts, and the neutrophil-to-lymphocyte ratio to predict recovery outcomes [8], particularly after events like acute ischemic stroke.

  • Systemic Inflammation Score (SIS)

The SIS is a robust predictor of Contrast Associated-Acute Kidney Injury (CA-AKI) incidence and long-term mortality risk. This score evaluates systemic inflammation and helps anticipate potential complications [9].

advanced inflammation scores

3. Epigenetic & DNA Test: A modern approach

As our understanding of inflammation score and its impact on health evolves, advanced methods for assessing inflammation are becoming increasingly important.

One such modern tool is the Epigenetics & DNA Test, which offers a personalized and detailed analysis of inflammation by examining epigenetic markers.

The Epigenetic & DNA Test analyzes specific chemical modifications to your DNA, known as epigenetic markers. These markers can indicate the presence and extent of chronic inflammation in your body. Here’s how the process typically works:

  • Collection of sample

The process begins with a simple saliva sample. This non-invasive method provides access to your full epigenetic and DNA health profile. The sample is then analyzed in a laboratory to detect specific epigenetic markers and DNA sequences.

  • Detailed health profile

The test generates an extensive health profile, including DNA and epigenetic results. This profile covers various aspects of health, from biological age to specific inflammation markers.

Epigenetic analysisDNA analysis
The epigenetic analysis focuses on inflammation by providing specific scores for overall inflammation, as well as pro-inflammatory and anti-inflammatory markers. These scores are crucial for understanding your body’s inflammatory status and potential health risks.The DNA analysis provides detailed reports on eye, gut, heart, mental, muscle, and skin health. It also includes metrics on sleep, stress, immunity, age, and injury, offering a comprehensive view of factors influencing inflammation.
  • Access through the mobile app

All results are accessible via the Longevity.Technology System mobile app. The app offers clinically referenced guidance tailored to your epigenetic and DNA profile, making it easy to understand and act on your results.

Through the Epigenetic & DNA Test, you gain valuable insights into your inflammation levels and overall health. This modern approach empowers you to take control of your well-being, leveraging advanced technology to enhance your longevity and quality of life.

What causes inflammation?

Inflammation is the body’s natural response to injury or infection, but it can also be triggered by various factors that lead to chronic health conditions. Here are the primary causes of inflammation [10]:

Infections

Infections caused by bacteria, viruses, fungi, and parasites can trigger acute inflammation. The body’s immune system responds to these pathogens by sending white blood cells to the affected area, resulting in redness, heat, swelling, and pain. 

Injuries

Physical injuries, including cuts, bruises, fractures, and burns, can cause acute inflammation as the body attempts to heal the damaged tissues. The inflammatory response helps to isolate the injury, prevent infection, and promote healing.

Autoimmune disorders

Autoimmune disorders occur when the immune system mistakenly attacks the body’s tissues, leading to chronic inflammation. These conditions can affect various organs and systems in the body.

Chronic diseases

Certain chronic diseases and conditions are associated with ongoing inflammation:

  • Diabetes
  • Cardiovascular diseases
  • Tumor growth

Types of inflammation

Inflammation is a complex biological response that can be categorized into two main types: acute and chronic. Each type of inflammation has distinct characteristics, causes, and health implications.

Acute inflammation is a vital part of the healing process, while chronic inflammation requires careful management to prevent long-term health complications [11].

AspectAcute inflammationChronic inflammation
DurationShort-term (days to weeks)Long-term (months to years)
OnsetRapidGradual and persistent
SymptomsRedness, heat, swelling, pain, loss of functionSubtle symptoms like fatigue, persistent pain
Primary functionProtective and healingCan become harmful and contribute to chronic diseases
Common causesInfections, injuries, allergic reactionsAutoimmune disorders, chronic infections, lifestyle factors

What are the 5 general signs of inflammation?

The classic signs of inflammation are crucial indicators that help identify your inflammation score and the presence of an inflammatory response. Here are the five main signs of inflammation [12], [13]:

1. Redness

Redness occurs due to increased blood flow to the affected area. When the body detects injury or infection, it dilates the blood vessels (a process called vasodilation) to allow more blood to reach the affected tissues.

Redness is typically visible on the skin’s surface in areas like cuts, scrapes, or infections. It may not be visible in internal organs but can still be detected through medical imaging.

2. Heat

Heat is a localized increase in temperature at the site of inflammation. This is another result of increased blood flow due to vasodilation. It is usually felt rather than seen and is most noticeable in areas close to the skin’s surface, such as around infected wounds or joints affected by arthritis.

3. Swelling

Swelling is the accumulation of fluid in the tissues surrounding the site of inflammation. This fluid buildup is known as edema. It can be seen as puffiness or enlargement in the affected area. Common examples include swollen joints, insect bites, or areas around infections.

4. Pain

Pain is a common and often distressing symptom of inflammation. It occurs when nerve endings in the inflamed area are stimulated.

Depending on the intensity of the inflammation and the area affected, pain can range from mild discomfort to severe agony. It is a crucial sign that signals the body to protect the injured area and avoid further damage.

5. Loss of function

Loss of function refers to the impaired ability of the affected area to function normally. This can include reduced mobility, strength, or flexibility in the inflamed tissue.

Loss of function is often noticeable in conditions like arthritis (where joint movement is restricted) or severe infections (where the function of the affected organ is compromised).

types of inflammation

How do you prevent inflammation?

Inflammation is a natural defense mechanism, but when it becomes chronic, it can lead to numerous health problems. Fortunately, there are several strategies to prevent and manage inflammation effectively:

  • Adopt an anti-inflammatory diet composed of fruits, vegetables, healthy fats, whole grains, lean proteins, herbs, and spices.
  • Engage in regular physical activity. Regular exercise helps lower levels of inflammatory markers such as CRP (C-reactive protein).
  • Chronic stress triggers the release of inflammatory chemicals, contributing to long-term inflammation. Manage stress effectively.
  • Get a restful sleep. Lack of sleep can disrupt hormones that regulate inflammation and immune function.
  • Regular check-ups can help monitor inflammation markers such as CRP and ESR, allowing for early detection and management.

Enhance your inflammation management with genetic insights

When considering managing and reducing your inflammation score effectively, it’s vital to understand the underlying genetic factors that influence inflammation responses.

The Longevity.Technology Epigenetic & DNA Test provides a powerful tool for gaining insights, enabling you to customize your diet and lifestyle to your genetic makeup, and optimize your inflammatory responses.

This test analyzes DNA to identify genetic predispositions related to inflammation, providing you with personalized recommendations to adjust your lifestyle.

For instance, if you’re genetically inclined to have a higher inflammatory response to certain foods or environmental factors, you can proactively make changes that significantly impact your health.

Final takeaways

Understanding and managing inflammation is crucial for maintaining optimal health and preventing chronic diseases. By recognizing the signs and symptoms of inflammation, you can take proactive steps to address its underlying causes. 

Small, consistent lifestyle changes can significantly reduce inflammation and improve quality of life. Stay informed, stay proactive, and prioritize your health.

Take the first step towards personalized inflammation management. Explore your genetic factors with our Epigenetic & DNA Test today!

FAQs

What does an inflammation score mean?

An inflammation score quantifies your body’s inflammation level using specific biomarkers. It helps assess your overall inflammatory status, indicating potential health risks and guiding personalized health strategies.

How can I naturally reduce inflammation in my body?

Adopt an anti-inflammatory diet rich in fruits, vegetables, and healthy fats. Regular exercise, stress management, and adequate sleep are also crucial.

What are the 4 markers of inflammation?

The four primary markers of inflammation are C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukins (such as IL-6), and tumor necrosis factor-alpha (TNF-α).

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500250/
[2] https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-023-03365-6
[3] https://www.dovepress.com/predictive-value-of-systemic-inflammation-score-for-contrast-associate-peer-reviewed-fulltext-article-JIR
[4] https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-09108-5
[5] https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/
[6] https://medlineplus.gov/lab-tests/erythrocyte-sedimentation-rate-esr/
[7] https://www.ajkd.org/article/S0272-6386%2811%2900725-6/fulltext
[8] https://www.researchgate.net/figure/The-calculation-of-low-grade-inflammation-score_fig1_354568409
[9] https://pubmed.ncbi.nlm.nih.gov/32839836/
[10] https://www.niehs.nih.gov/health/topics/conditions/inflammation
[11] https://www.health.harvard.edu/staying-healthy/understanding-acute-and-chronic-inflammation
[12] https://www.verywellhealth.com/signs-of-inflammation-4580526
[13] https://www.medicalnewstoday.com/articles/248423

Photograph: Unai82/Envato
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