$125m secured for xenotransplantation human trials

Series C proceeds will advance two lead xenotransplantation programmes in kidney failure and type 1 diabetes into first-in-human studies.

eGenesis, a gene-editing and genome-engineering company developing human-compatible organs, tissues and cells, today announced the successful completion of a $125 million Series C financing. Funding will be used to bring the company’s lead programmes in kidney and islet cell transplant into human proof-of-concept $125m secured for xenotransplantation human trials studies. In addition, the funds will be used for continued development of the company’s proprietary gene-editing platform and scaling of GMP production.

Longevity.Technology: The demand for lifesaving organs far outnumbers available supply. In the US alone, more than 110,000 people are on the national transplant list. 20 people die every day due to lack of available organs for transplant and every 10 minutes a new name is added to the national transplant waitlist.

The concept of xenotransplantation (the transplantation of organs, tissue, and cells from one species to another) has been explored for decades, with the pig considered the most suitable donor for humans. However, virology and immunology hurdles prevented the field from advancing beyond early preclinical research. With the advent of advanced gene editing technologies, addressing these historical challenges is now within reach.

eGenesis is on a mission to transform the field of transplantation by offering safe and effective organs, tissues and cells to patients in need. By harnessing gene editing technologies, eGenesis plans to tackle the obstacles that have impeded xenotransplantation to date, and its development pipeline includes lead programmes for kidney and islet cell transplant as well as earlier-stage programmes focused on other solid organs

The financing from leading healthcare investors included Farallon Capital Management, Polaris Partners, HBM Healthcare Investments, Invus, Samsara BioCapital, LifeSci Venture Partners, Irving Investors, Catalio Capital Management, SymBiosis, Altium Capital, Monashee Investment Management and Osage University Partners. Existing investors including Leaps by Bayer, Fresenius Medical Care Ventures, ARCH Venture Partners, Wellington Partners, Khosla Ventures, and Alta Partners also participated.

“With this financing we are now well positioned to address two of the greatest disease burdens in the US and global healthcare systems.”

In conjunction with the closing of the financing, Isaac Ciechanover, MD, from Polaris Partners, and Mark Pruzanski, MD, Founder and former Chief Executive Officer of Intercept Pharmaceuticals, joined the eGenesis Board of Directors.

“We are proud of the progress we are making in our mission to help solve the global organ shortage,” said Paul Sekhri, President and Chief Executive Officer of eGenesis. “We thank our new and current investors for their vote of confidence. With this financing we are now well positioned to address two of the greatest disease burdens in the US and global healthcare systems.”

“eGenesis has developed a scientific platform that will transform transplant medicine,” Srini Akkaraju, MD, PhD, Founder and Managing General Partner at Samsara BioCapital added. “We are excited about the progress that eGenesis has made in kidney and islet cell transplant which could address the fast-growing unmet need for patients with kidney failure and type 1 diabetes.”

Image courtesy of eGenesis