‘Address brain aging and push back cognitive decline’

NMN Bio founder discusses new supplement NAD+ Brain and explains why optimizing for slower brain aging and reduced cognitive decline is a no brainer.

NAD+ plays a critical role in molecular pathways that keep our bodies running, growing and repairing. As well as NAD+ demonstrating some antiaging properties, raising the levels of this essential co-enzyme in the body shows promising results when it comes to the fight against age-related cognitive decline [1]. However, levels of NAD+ diminish with age, and this is where NMN comes in. NMN – or nicotinamide mononucleotide – is a naturally-occurring direct precursor of NAD+; increasing the amount of NMN building blocks available encourages the body to up the levels of NAD+ and thus help stem cognitive decline.

Longevity.Technology: As longevity supplements grow in popularity, so too do the number of products. While some are highly pure and of reputable provenance, others are less so. When Elena Seranova, who holds an MSc in Translational Neuroscience and a PhD in Stem Cell Biology and Autophagy, couldn’t find a reliable supplier of NMN for herself and her family, she started her own company. Now her company’s product line has expanded to include NAD+ Brain, a nootropic designed to improve focus and concentration, slow down aging in the brain, guard the brain from oxidative stress and inflammation, and preserve NAD+ in the brain. We caught up with Dr Seranova to find out more about NMN Bio‘s new product line.

Elena Seranova on…

Pushing back cognitive decline

We have now launched our first proprietary product, which is called NAD+ Brain; there’s nothing like it on the market – it’s a very unique formulation.

Earlier this year, we published in Cell Reports and showed a very interesting connection between autophagy and NAD metabolism. We saw multiple pathophysiological processes going wrong in the neuronal cells that we were studying in neurodegeneration, and saw phenotypes with dysfunctional mitochondria and impaired autophagy. Autophagy declines with age, and in the dysfunctional neurons, we observed increased reactive oxygen species and dysfunctional mitochondria floating around. And the reason was dysfunctional autophagy in those cells. When you have increased reactive oxygen species, you start having increased DNA damage, which leads to hyperactivation of enzymes such as PARPs and sirtuins which need to consume NAD+ in order to deal with the DNA repair.

NAD declines with age and then autophagy declines with age and then mitochondrial function declines with age as well – it’s a very clearly defined phenotype. And then I considered all the different supplements that I’m taking myself, and realised that a third of the supplements I’m actually taking for my brain. So, I asked myself how can this be optimized? How can I put this in one supplement? I started looking at the different hallmarks of brain aging, looking at decreasing neurotransmission, decreasing concentration and focus, neuroinflammation and decline in the function of the vasculature system in the brain – there are multiple pathologies that are going on after the age of 30 or 40 and it’s all just a downward spiral from there.

NAD+ Brain is designed to address all of those hallmarks of brain aging, and provide short-term benefits. It boosts the baseline of your neurotransmission with neurotransmitters, increasing the baseline of cognitive ability on a daily basis and providing stress-free, jitter-free cognitive energy. We put together ingredients that will nurture your brain and will give you all the nutrients so you can basically stop and push back the cognitive decline.

Something different is a no brainer

We wanted to differentiate this product from everything else on the market, so all the ingredients are blood brain barrier permeable. This supplement is specifically formulated to support your brain, so it was a no brainer – no pun intended – to make sure that all of the ingredients are actually reaching your your brain. The formulation includes cofactors such as phosphatidylserine and vitamin B5 work to increase absorption and help the other ingredients to get into your brain.

NAD+ Brain contains 12 ingredients, and we have also included ingredients that are proven to boost your cognitive performance such as zinc and vitamin B5. It has been shown that deficiency of vitamin B5 and B6, which is also an ingredient, is tied to neurodegeneration. We’ve been working on this for just under two years, going back and forth with our R&D team, our biochemistry team and our nutritionist team to make sure that we fine tune the dosage of the ingredients to have the synergistic effect that we are now achieving.

We pride ourselves in our supply chain transparency, and in the fact that we are third party testing all of our products at every batch to make sure that it’s pure, clean, there are no heavy metals or microorganisms in our products.

We felt we wanted to do something good for the world and offer a high quality supplement as fast as possible. We had seen the data and statistics for mild cognitive decline, which is something like over 20% of people over the age of 60 will get mild cognitive decline. And those are statistics from 2021 – it’s even higher now.

NMN Bio’s plans for the future

As part of our partnership with Aster Pharmacy, NAD+ Brain will hit the stores in 2024. We are also looking into expanding more into the Middle East and other Gulf countries, and we’re already in talks with other distributors. There is another super-exciting collaboration that we’re going to launch next year, and while I can’t comment more on that at the moment, we’re going to enter another huge market for antiaging supplements, and have our products in another country’s stores.

In terms of clinical studies, there will be more data coming out of the University of Birmingham, which is the university at which that I did my PhD project; we are still working closely working with my PhD lab and looking into how we can organize a human clinical study in order to show efficiency for NAD+ Brain as well.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370773/