Lifespan innovations: Highlights from Longevity Summit Dublin

Dominika Wilczok reports on this year’s Summit, where top experts explored breakthroughs in aging research and future healthspan innovations.

Days 3 and 4 of Longevity Summit Dublin were a testament to the conference’s dynamic and forward-thinking spirit. Packed with insightful presentations and robust discussions, these days covered all sorts of longevity science and examined how it can be leveraged to meaningfully expand both healthspan and lifespan. From the unveiling of innovative AI platforms and breakthroughs in DNA repair to in-depth explorations of female reproductive longevity and governmental roles in healthspan funding, the summit showcased a rich tapestry of cutting-edge research and collaboration. Engaging keynotes, lively panel discussions and vibrant networking events, including a memorable Gala Dinner, ensured that the excitement and momentum never waned.

Here is a flavor of some of the highlights and key takeaways from these two pivotal days, capturing the essence of an event that is propelling the field of longevity into a promising future. Wish you’d be there? Make sure you join us in 2025!

DAY 3

Ben Goertzel started the day by presenting the Bioatomspace, the large language model fed with biological datasets, research papers and medical records, then trained again on logical expressions. Dr Alex Zhavoronkov, the CEO of Insilico Medicine, the world leader in AI drug discovery, explained the power of multimodal, multiagent, multispecies platforms for advancing longevity research. Hanadie Yousef from Juvena Therapeutics presented the strategy of leveraging proteins in cell secretomes for longevity. Its platform, JuveNET, aims to accelerate drug discovery and development. Ivan de Weber from Cortex Discovery went over their foundation model for drug property predictions and molecular docking.

The following module about DNA damage and repair was opened by Bjorn Schumacher, giving a keynote on pan-mammalian aging clocks and stochastic variation. Joris Deelen explained the novel loci associated with healthy aging and the progress in the study of the effect of rare protein-altering genetic variants in long-lived individuals. Morten Scheibye-Knudsen enriched the module by discussing sex- and tissue-specific aging pathome and mapping cellular senescence.

Simisola Oke from GlycanAge, which was an event sponsor and also offered on-site testing, convinced the audience that estrogen is a longevity therapeutic.

After the lunch break, the discussion moved to female reproductive longevity, the topic that is finally getting the attention it deserves. Niamh Joyce, Maria Marinova and Miguel Brieño-Enriquez shared their insights on how the research and interventions are advancing, including NAD+ boosters, ovarian reserve influencing factors and demographic changes. The researchers concluded the module with an insightful panel with Tamara Radaković, Stasa Stankovic, and Jennifer Pearlman.

The concluding part of the day was about governments’ involvement in longevity. We heard from William Greene from the Hevolution Foundation, which recently mobilized a $400 million surge in healthspan funding. Michael Suk and Trey Goff continued the conversation by emphasizing the need for communication and cooperation.

Maria Blasco finished with the most recent findings on one of the hallmarks of aging: telomere shortening. She reported her lab’s latest findings on the study of telomeres and telomerase and their role in human disease.

DAY 4

One might think that at the fourth day of a science conference, there might be some signs of flagging or attention wandering. It is a testament to the success of Longevity Summit Dublin that its exciting speaker lineup successfully prevented that from happening. Rozalyn Anderson, Holly Brown-Borg, Matthew Scholz and Jana Buzkova explored the role of metabolism in aging touching upon topics such as the neurobiology of healthy aging, senolytics, NAD+ supplementation, protein restriction and growth hormones.

The next module focused on personalized and targeted therapies. Kotb Abdelmohsen, Lou Hawthorne and Brian Kennedy gave keynotes that showed the progression of personalized medicine overall, while Alexandru-Ioan Voda showed how these interventions can be tested in a cat model.

Continuing the conversation from the day before, Kamen Shoylev, Laurence Ion, Melissa King, Didier Coeurnelle and Jose Cordeiro focused on the legal and regulatory ecosystems that longevity entrepreneurship and scientists have to deal with if they want to do anything other than consuming others’ work. The field that is still very much in production is the research of novel species and strains in longevity. Georg Fuellen, Matae Ahn, Alec Lackmann, Emma Teeling and Kennedy Schaal discussed this cutting-edge space.

The day concluded with a fireside chat between Alberto Aparicio and Aubrey de Grey.

But still so much to report!

The conference also provided a lot of fun, with multiple opportunities to network. A longevity 5k fun run raised participants’ heart rates, powering them with an endorphins boost for the day. Multiple snack and coffee breaks in the all-standing mode got people mingling and talking, debating ideas and continuing discussions as well as building up an appetite for the evening social gatherings. At Saturday’s Gala Dinner, even the most engrossing conversations were put on hold when the drummer clad in Viking-like clothing took to the stage, beating out the rhythm for the waiters who turned out to be tap dancers in disguise – we really got to feel some Irish spirit!

Two awards were distributed. Alexander Fedintsev was named the “rising star” of longevity research. Aubrey de Grey admitted that Alexander had managed to change Aubrey’s mind, something that was one of the many reasons for the award. Dr Maria Blasco received the Outstanding Contribution Award, a beautiful parchment painting inspired by an ancient Irish artifact and created by the hand of Randy Hess, the artist on site.

Outstanding Contribution Award, presented to Dr Maria A Blasco and designed and created by Randy Hess

Longevity Summit Dublin was certainly an event to remember! Likely to be celebrated as a time when many projects began, it, and other events like it, has the potential to transforming the landscape of longevity science. This summit was more than just a series of presentations – it was a dynamic hub where ideas were exchanged, collaborations were forged and the future of aging research was charted. Attendees left inspired and energized, ready to push the boundaries of what is possible in longevity science. As we look forward to next year’s summit, the innovations and connections born from this gathering promise to significantly advance our understanding and enhancement of human lifespan and healthspan.

Read Dominika’s round-up of Days 1 and 2 HERE.


About Dominika Wilczok

With a background in using AI for early Alzheimer’s detection, advocating against ageism, and establishing an NGO centered around Healthy Longevity, for 5 years, Dominika has been working to close the healthspan-lifespan gap. Her current work encompasses longevity medicine, and AI-driven approaches to end aging, and you can watch her TEDX talk on longevity medicine, aging research and AI HERE.