
Leading researcher highlights potential of ergothioneine in prevention and treatment of age-related disease.
At next weekβs Society for Free Radical Research (SFRR) International meeting, one of the most interesting presentations from a longevity perspective will focus on the role of ergothioneine in the body. Present throughout our bodies and taken up through our diet (particularly from mushrooms), this powerful antioxidant is increasingly thought to play a role in protecting against age-related and neurodegenerative disease.
Longevity.Technology: The SFRR International presentation will be delivered by one of the worldβs leading researchers on free radicals and antioxidants in biological systems, Professor Barry Halliwell from the National University of Singapore. We spoke recently with Prof. Halliwell to find out more about ergothioneine and its longevity potential.

Sponsored by Longevity.Technology
Society for Free Radical Research
Online Congress: 15β18 March 2021
For decades, Halliwellβs research has focused on free radicals and antioxidants, and the role they play in human disease.
βIn particular, we’re interested in neurodegenerative diseases, Alzheimer’s, the other dementias, and Parkinson’s disease, both from the point of view of prevention and treatment,β he says, pointing out that the brains of people who have died from these diseases show remarkably high levels of oxidative damage.
βIt’s as if there’s increased free radical production or failure of scavenging, or failure to remove oxidatively damaged molecules,β adds Halliwell.
βWhich raises the question of why haven’t people used antioxidants to treat these diseases?β
On the prevention side, studies have shown that high intake of vitamin D, vitamin C, carotenoids and flavonoids from diet are neuroprotective, but Halliwell says that clinical trials on single compounds, such as high dose vitamin E or vitamin C, havenβt delivered positive results. He is hopeful that ergothioneine, a compound heβs worked on since the 1980s, will buck this trend.
βThere was a lot of interest in ergothioneine in the 1950s and 60s, we characterised its antioxidant properties in the 1980s, and then everybody lost interest in it.β
Until 2005 that is, and the discovery of a specific transporter that brings ergothioneine into the human body.
βFor things like carotenoids, flavonoids, as far as we know, there’s no specific transporter, but there are for important metals that we need, like zinc and iron and for vitamin C and B vitamins and so on,β explains Halliwell.
βSo the fact that there is a transporter suggests that ergothioneine is important.β
Then, purely by accident, Halliwell found blood levels of ergothioneine were significantly down in people with mild cognitive impairment, the early stage of dementia.
βSince then we’ve been involved in a mega study, which confirmed, in a very large population, that as people start to develop cognitive impairment, blood levels of ergothioneine drop, and then as they go on to full blown dementia, they drop further,β he says. βNow, this is just pure correlation, so we’ve started a double-blind, placebo-controlled clinical trial of feeding ergothioneine to people with MCI to see if it helps them.β
The COVID-19 pandemic struck just as the trial at NUS was getting started, so it was stopped and has only just restarted again, and Halliwell is hopeful that heβll able to share results in around a yearβs time.
In other areas of research, Halliwell is looking at the effect of ergothioneine in a number of animal models of dementia and Parkinson’s disease, where he says it has shown to be quite effective.
βWeβre also the first group in the world to be allowed to administer pure ergothioneine to healthy human subjects, and showed that it is avidly retained,β he adds.
βUnlike some compounds that have been tested, it also seems to go into the brain.β
In addition to exploring ergothioneineβs potential for the treatment of COVID-19 patients, Halliwellβs department has also received a Healthy Longevity Catalyst Award from the National Academy of Medicine.
βWeβre going to investigate this idea that ergothioneine might be a longevity vitamin,β he says. βWe’ve generated mice that don’t have the transporter, so they can’t take in ergothioneine. Phenotypically, when they’re young, they seem quite normal β it doesn’t seem to bother them, but we’re now looking at how well they age, which of course takes time.β
So does Halliwell think that people should consider boosting their intake of ergothioneine?
βWell, I have noticed I eat more mushrooms than I used to, but again, youβve got to be careful,β he says. βMushrooms contain a lot of things and they contain low levels of certain toxins, so you don’t want to overdo it.β