Groq Health founder says longevity medicine needs to take an N-of-1 approach to predicting an individual’s health trajectory.
A new AI-powered app is using a personalized precision medicine approach to help people slow, or even reverse, their biological aging. Created by US precision medicine practitioner Dr Florence Comite, Groq Health interprets users’ genomic, metabolic, phenotypic, and digital health data into personalized action plans designed to improve healthspan, and hopefully prevent the onset of disorders like obesity, diabetes, heart disease, cancer, and dementia.
With its consumer launch not expected until later next year, a version of the app is currently being pilot tested by businesses as a corporate health benefit for employees, and is boasting positive early results.
Longevity.Technology: A precision medicine approach typically refers to the prevention and treatment of diseases based on the unique makeup of an individual’s genes, environment and lifestyle. With Groq Health, Comite is combining her precision medicine expertise with 20 years of longitudinal clinical outcome data to help people boost their healthspan and longevity. We caught up with Comite to learn more about her work and how it led to the development of the new app.
As a clinician and academic who has spent her career “predicting, preventing, and reversing” chronic disease and disorders associated with aging, it’s fair to say that Comite has been practicing “longevity medicine” long before the term existed.
“I love the word longevity – although I prefer ‘healthy longevity,’” she says. “To me, it was always about achieving a healthspan that match your lifespan.”
‘Prospective’ health analysis
In 2005, Comite founded the Comite Center for Precision Medicine & Health in Manhattan, NY, where every patient is treated as though they were in an N-of-1 clinical trial (a study where each patient is the sole subject).
“Clinical studies and trials often look at hundreds or thousands of people, thinking if you can gather enough people, you’ll be able to get significance,” she says. “Well, I think the opposite. I think we need to look at people individually to see how they differ over time and what their response is to a particular drug or exercise or supplement or intervention. And that’s what I designed – I designed a way to look at people’s health prospectively, or ahead of time.”
From losing body fat and improving sleep to enhancing sexual function and building muscle, Comite says her methods have consistently delivered positive results for her patients over the years. To prove her point, she brings up the Rejuvenation Olympics leaderboard, where five of the top 20 biological age reversers are clients at her clinic.
From bricks to clicks
However, there are only so many people you can treat at a bricks-and-mortar clinic, which led Comite to the idea of a “digital clinic” that would allow broad access to her precision medicine approach.
“Believe it or not, I’ve wanted to do this since 1998,” she says. “At that time, I knew if I could prove that I could identify people’s future health trajectory, and help prevent age-related diseases before symptoms emerge, then everybody should have access to it because it would revolutionize how people were living and how they would grow old. And now the time is right, because now we have machine learning, AI and generative AI, and we have already created the protocol, the patterns, so we know what it speaks to.”
The Groq Health app analyzes biomarkers such as sleep, nutrition and exercise, alongside personal and family health history and a broad range of health data from blood tests, wearables and more. The app’s algorithms draw on longitudinal data collected from the thousands of patients treated by Comite over the past two decades to provide users with insights and tailored interventions.
“Most health apps are modeled on generalized data bought from insurance companies and pharmaceutical reports, not real people or the doctors who have gotten to know and understand their patients over time,” says Comite. “Coming from a medical background, I take it very seriously. I think of it as virtual medicine, not just a digital app to help you get fit or eat right. For me, it all has to come together in order to make a difference to a person. From just a handful of biomarkers, we can tell what’s brewing and why – we can tell you the risks you have today, and we have the data to back it up.”
While the specific biomarkers that Groq is analyzing are proprietary at this stage, Comite does say that the app comes with a prescription for a continuous glucose monitor, so it’s safe to say that blood sugar is on the menu.
“Sugar affects a lot of body function – it’s always circulating, it’s critical for every organ, but it can also damage every cell in the body, from brain cells to kidney cells to skin cells… it just depends on your genetic variant as to how it will express,” she says. “So yes, sugar is critical, because it’s a big, big factor in chronic disease.”
Promising beta results
Comite reveals that the Groq app is now in pilot testing at a handful of US companies, although a consumer launch is not far away.
“We’re going to roll out to consumers next year, but we’re starting out with select companies because it’s early and we’re still small,” she says. “We’re working with self-insured corporations that want to keep their people in great shape.”
Looking at early data coming from Groq’s corporate program, Comite says that almost all users have improved their sleep quality, enhanced energy levels, lost fat and gained lean muscle mass, and that many have even reversed cases of prediabetes and diabetes.
To date, Groq has raised approximately $7 million from individual investors, including Munjal Shah, co-founder of medical education technology company Hippocratic AI, and Howard Morgan, chairman of multibillion-dollar investment firm B Capital Group.
“I know Florence deeply feels a passion for trying to democratize longevity and democratize the quality of care that she provides at the Comite Center,” says Shah. “The opportunity here [with Groq Health] is really to bring longevity work to more people. There’s a tremendous health equity opportunity here that isn’t just about how a few people on Central Park South can have access to this but everyone in the world should be able to live a better, what Florence calls healthspan – not just how long you live but how well you live during those years that you live long.”