Oxygen restriction enhances lifespan of rapidly aging mice

Less really is more – research suggests for first time that reduced oxygen intake might extend mammalian lifespan.

For the first time, breathtaking [sorry] research has shown that reduced oxygen intake, or oxygen restriction, is associated with longer lifespan in lab mice, highlighting its antiaging potential.

Longevity.Technology: If you hear the word “restriction” when it comes to lifespan extension, you probably think the subject being discussed is caloric restriction, which has been shown to extend lifespan in nematodes, flies, mice, rats and primates. Oxygen restriction has also been linked to longer lifespan in yeast, worms and fruit flies, but until now, its effects in mammals have been unknown.

To explore the antiaging potential of oxygen restriction in mammals, Robert Rogers of Massachusetts General Hospital in Boston and colleagues conducted lab experiments with mice bred to age more quickly than other mice while showing classic signs of mammalian aging throughout their bodies.

The researchers compared the lifespans of mice living at normal atmospheric oxygen levels (about 21 percent) with the lifespans of mice that, at 4 weeks of age, had been moved to a living environment with a lower proportion of oxygen (11 percent – similar to that experienced at an altitude of 5000 meters).

They found that the mice in the oxygen-restricted environment lived about 50 percent longer than the mice in normal oxygen levels, with a median lifespan of 23.6 weeks compared with 15.7 weeks. The oxygen-restricted mice also had delayed onset of aging-associated neurological deficits [1].

Prior research has shown that dietary restriction extends the lifespan of the same kind of fast-aging mice used in this new study [2]; this led the researchers to wonder if oxygen restriction extended their lifespan simply by causing the mice to eat more. However, they found that oxygen restriction did not affect food intake, suggesting other mechanisms were at play.

These findings, which have been published in the open access journal PLOS Biology, support the antiaging potential of oxygen restriction in mammals, perhaps including humans. However, extensive additional research will be needed to clarify the potential benefits and illuminate the molecular mechanisms by which it operates.

Rogers says: “We find that chronic continuous hypoxia (11% oxygen, equivalent to what would be experienced at Everest Base Camp) extends lifespan by 50% and delays the onset of neurologic debility in a mouse aging model.

“While caloric restriction is the most widely effective and well-studied intervention to increase lifespan and healthspan, this is the first time that ‘oxygen restriction’ has been demonstrated as beneficial in a mammalian aging model [3].”

[1] https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002117
[2] https://www.nature.com/articles/nature19329
[3] https://www.eurekalert.org/news-releases/989438