Smartphone-sized bioartificial kidney prototype passes key test

The Kidney Project successfully tests a prototype bioartificial kidney and wins KidneyX’s $650,000 Artificial Kidney Prize.

The Kidney Project’s implantable bioartificial kidney, one that promises to free kidney disease patients from dialysis machines and transplant waiting lists, took another big step toward becoming reality, earning a $650,000 prize from KidneyX for its first-ever demonstration of a functional prototype of its implantable artificial kidney.

Longevity.Technology: Chronic kidney failure, also known as end-stage renal disease, leads to the progressive and dangerous loss of kidney function. Most patients with kidney failure must visit dialysis clinics multiple times every week to have their blood filtered, a process that is time-consuming, uncomfortable and risky.

A minority of patients live with transplanted kidneys, thanks to a pool of donated kidneys, the demand for which far outstrips supply. However, even these patients must contend with a lifetime on immunosuppressant drugs that can have severe side effects. Organoids and xenotransplants are other areas being explored, but the idea of an artificial kidney that is rejection-free, easily transported and maybe even upgradeable and reusable is very appealing. Kidney disease is debilitating and often fatal, having a devastating effect on both lifespan and healthspan – perhaps, now, there is an artificial light at the end of the tunnel.

KidneyX is a public–private partnership between the US Department of Health and Human Services (HHS) and the American Society of Nephrology (ASN) founded to “accelerate innovation in the prevention, diagnosis and treatment of kidney diseases.”

The Kidney Project, a nationwide collaboration led by Shuvo Roy, PhD of UC San Francisco and William Fissell, MD of Vanderbilt University Medical Center (VUMC), combined the two essential parts of its artificial kidney, the hemofilter and the bioreactor, and successfully implanted the smartphone-sized device for preclinical evaluation.

For this advance, the team was awarded KidneyX’s Phase 1 Artificial Kidney Prize and was one of six winning teams selected out of an international field.

Prototype bioartificial kidney passes key test_1
Prototype bioartificial kidney passes key test

In the last few years, The Kidney Project successfully tested the hemofilter, which removes waste products and toxins from blood and the bioreactor, which replicates other kidney functions, like the balance of electrolytes in blood, in separate experiments.

For the Artificial Kidney Prize, the team married the two units into a scaled-down version of the artificial kidney and evaluated its performance in a preclinical model. The units worked in tandem, powered by blood pressure alone and without the need for blood thinning or immunosuppressant drugs.

“The vision for the artificial kidney is to provide patients with complete mobility and better physiological outcomes than dialysis,” said Roy, who is a faculty member in the Department of Bioengineering and Therapeutic Sciences, a joint department of the UCSF Schools of Pharmacy and Medicine. “It promises a much higher quality of life for millions worldwide with kidney failure [1].”

The Kidney Project’s artificial kidney will not only replicate the high quality of life seen in kidney transplant recipients – the “gold standard” of kidney disease treatment, according to Roy – but also spare them from needing to take immunosuppressants.

“Our team engineered the artificial kidney to sustainably support a culture of human kidney cells without provoking an immune response,” said Roy. “Now that we have demonstrated the feasibility of combining the hemofilter and bioreactor, we can focus on upscaling the technology for more rigorous preclinical testing and, ultimately, clinical trials [1].”

The KidneyX Artificial Kidney Prize called on scientists and engineers to submit “continuous kidney replacement therapies that provide transformational treatment options beyond current dialysis methods,” a high bar that UCSF’s artificial kidney is poised to clear in the coming years.

“This award is a testament to The Kidney Project’s bold vision and execution of a viable solution for millions of patients with kidney failure,” said UCSF School of Pharmacy Dean B Joseph Guglielmo, PharmD [1].


Image by Courtesy of UCSF